Kenneth C McCullough
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Explore the profile of Kenneth C McCullough including associated specialties, affiliations and a list of published articles.
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Articles
57
Citations
1163
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Recent Articles
1.
Demoulins T, Techakriengkrai N, Ebensen T, Schulze K, Liniger M, Gerber M, et al.
Methods Mol Biol
. 2024 May;
2786:89-133.
PMID: 38814391
While mRNA vaccines have shown their worth, they have the same failing as inactivated vaccines, namely they have limited half-life, are non-replicating, and therefore limited to the size of the...
2.
Demoulins T, Schulze K, Ebensen T, Techakriengkrai N, Nedumpun T, Englezou P, et al.
Nanomedicine
. 2023 Jan;
49:102655.
PMID: 36681171
Herein, we provide the first description of a synthetic delivery method for self-replicating replicon RNAs (RepRNA) derived from classical swine fever virus (CSFV) using a Coatsome-replicon vehicle based on Coatsome®...
3.
Demoulins T, Ruggli N, Gerber M, Thomann-Harwood L, Ebensen T, Schulze K, et al.
Front Immunol
. 2021 Feb;
11:622385.
PMID: 33584723
Self-amplifying replicon RNA (RepRNA) promotes expansion of mRNA templates encoding genes of interest through their replicative nature, thus providing increased antigen payloads. RepRNA derived from the non-cytopathogenic classical swine fever...
4.
Rapoport E, Moiseeva E, Aronov D, Khaidukov S, Pazynina G, Tsygankova S, et al.
Glycoconj J
. 2019 Dec;
37(1):129-138.
PMID: 31834559
Modification of vaccine carriers by decoration with glycans can enhance binding to and even targeting of dendritic cells (DCs), thus augmenting vaccine efficacy. To find a specific glycan-"vector" it is...
5.
Englezou P, Sapet C, Demoulins T, Milona P, Ebensen T, Schulze K, et al.
Mol Ther Nucleic Acids
. 2018 Sep;
12:118-134.
PMID: 30195751
Advances in RNA technology during the past two decades have led to the construction of replication-competent RNA, termed replicons, RepRNA, or self-amplifying mRNA, with high potential for vaccine applications. Cytosolic...
6.
Rapoport E, Khaidukov S, Gaponov A, Pazynina G, Tsygankova S, Ryzhov I, et al.
Glycoconj J
. 2018 Feb;
35(2):191-203.
PMID: 29388006
Dendritic cells (DCs) play crucial roles in innate and adaptive immune response, for which reason targeting antigen to these cells is an important strategy for improvement of vaccine development. To...
7.
Ebensen T, Debarry J, Pedersen G, Blazejewska P, Weissmann S, Schulze K, et al.
Front Immunol
. 2017 Oct;
8:1223.
PMID: 29033942
The need for more effective influenza vaccines is highlighted by the emergence of novel influenza strains, which can lead to new pandemics. There is a growing population of susceptible subjects...
8.
Demoulins T, Ebensen T, Schulze K, Englezou P, Pelliccia M, Guzman C, et al.
J Control Release
. 2017 Sep;
266:256-271.
PMID: 28935594
The major limitations with large and complex self-amplifying RNA vaccines (RepRNA) are RNase-sensitivity and inefficient translation in dendritic cells (DCs). Condensing RepRNA with polyethylenimine (PEI) gave positive in vitro readouts,...
9.
Sharma R, Ghasparian A, Robinson J, McCullough K
J Immunol
. 2017 Jun;
199(2):734-749.
PMID: 28630093
Dendritic cells (DCs) play critical roles in developing immune defenses. One important aspect is interaction with pathogen-associated molecular patterns (PAMPs)/danger-associated molecular patterns, including di- and triacylated lipopeptides. Isolated or synthetic...
10.
Demoulins T, Englezou P, Milona P, Ruggli N, Tirelli N, Pichon C, et al.
Methods Mol Biol
. 2016 Dec;
1499:37-75.
PMID: 27987142
Most current vaccines are either inactivated pathogen-derived or protein/peptide-based, although attenuated and vector vaccines have also been developed. The former induce at best moderate protection, even as multimeric antigen, due...