Kelvin H Lee
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Explore the profile of Kelvin H Lee including associated specialties, affiliations and a list of published articles.
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146
Citations
2115
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Recent Articles
1.
Szkodny A, Lee K
Biotechnol J
. 2025 Jan;
20(1):e202400520.
PMID: 39834086
The implementation of site-specific integration (SSI) systems in Chinese hamster ovary (CHO) cells for the production of monoclonal antibodies (mAbs) can alleviate concerns associated with production instability and reduce cell...
2.
Reddy J, Leibiger T, Singh S, Lee K, Papoutsakis E, Ierapetritou M
Biotechnol Bioeng
. 2024 Dec;
122(4):761-778.
PMID: 39740206
The CHO VRC01 cell line produces an anti-HIV IgG1 monoclonal antibody containing N-linked glycans on both the Fab (variable) and Fc (constant) regions. Site-specific glycan analysis was used to measure...
3.
Leibiger T, Min L, Lee K
Mol Ther Methods Clin Dev
. 2024 Dec;
32(4):101383.
PMID: 39691383
To better understand host cell protein (HCP) retention in adeno-associated virus (AAV) downstream processes, sequential window acquisition of all theoretical fragment ion mass spectra (SWATH-MS) was used to quantitatively profile...
4.
Reddy J, Singh S, Leibiger T, Lee K, Ierapetritou M, Papoutsakis E
Metab Eng
. 2024 Nov;
87:37-48.
PMID: 39577620
Culture conditions have a profound impact on therapeutic protein production and glycosylation, a critical therapeutic-quality attribute, especially for monoclonal antibodies (mAbs). While the critical culture parameter of pH has been...
5.
Leibiger T, Remmler L, Green E, Lee K
Mol Ther Methods Clin Dev
. 2024 Sep;
32(3):101306.
PMID: 39220638
Faster and more accurate analytical methods are needed to support the advancement of recombinant adeno-associated virus (rAAV) production systems. Recently, biolayer interferometry (BLI) has been developed for high-throughput AAV capsid...
6.
Szkodny A, Lee K
Biotechnol Prog
. 2024 Apr;
40(5):e3466.
PMID: 38607316
Monoclonal antibodies (mAbs) are often engineered at the sequence level for improved clinical performance yet are rarely evaluated prior to candidate selection for their "developability" characteristics, namely expression, which can...
7.
Oh Y, Becker M, Mendola K, Choe L, Min L, Lee K, et al.
Biotechnol Bioeng
. 2024 Jan;
121(4):1284-1297.
PMID: 38240126
Product association of host-cell proteins (HCPs) to monoclonal antibodies (mAbs) is widely regarded as a mechanism that can enable HCP persistence through multiple purification steps and even into the final...
8.
9.
Cordova L, Dahodwala H, Cooley R, Lee K
Biotechnol J
. 2023 Nov;
19(1):e2300425.
PMID: 37970758
Chinese hamster ovary (CHO) cells are essential to biopharmaceutical manufacturing and production instability, the loss of productivity over time, is a long-standing challenge in the industry. Accurate prediction of cell...
10.
Oh Y, Mendola K, Choe L, Min L, Lavoie A, Sripada S, et al.
Biotechnol Bioeng
. 2023 Oct;
121(1):291-305.
PMID: 37877536
Host-cell proteins (HCPs) are the foremost class of process-related impurities to be controlled and removed in downstream processing steps in monoclonal antibody (mAb) manufacturing. However, some HCPs may evade clearance...