Kelsi O West
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Explore the profile of Kelsi O West including associated specialties, affiliations and a list of published articles.
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6
Citations
154
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Recent Articles
1.
Wagner A, Weindel C, West K, Scott H, Watson R, Patrick K
Elife
. 2022 Nov;
11.
PMID: 36409059
To mount a protective response to infection while preventing hyperinflammation, gene expression in innate immune cells must be tightly regulated. Despite the importance of pre-mRNA splicing in shaping the proteome,...
2.
Sengupta S, West K, Sanghvi S, Laliotis G, Agosto L, Lynch K, et al.
Immunohorizons
. 2021 Oct;
5(10):884-897.
PMID: 34716181
Protein arginine methyltransferase (PRMT) 5 is the type 2 methyltransferase catalyzing symmetric dimethylation of arginine. PRMT5 inhibition or deletion in CD4 Th cells reduces TCR engagement-induced IL-2 production and Th...
3.
Wagner A, Scott H, West K, Vail K, Fitzsimons T, Coleman A, et al.
Front Immunol
. 2021 Jul;
12:656885.
PMID: 34305890
Pathogen sensing pattern recognition receptors triggers massive reprogramming of macrophage gene expression. While the signaling cascades and transcription factors that activate these responses are well-known, the role of post-transcriptional RNA...
4.
Hoffpauir C, Bell S, West K, Jing T, Wagner A, Torres-Odio S, et al.
J Immunol
. 2020 May;
205(1):153-167.
PMID: 32404352
Tripartite motif-containing proteins (TRIMs) play a variety of recently described roles in innate immunity. Although many TRIMs regulate type I IFN expression following cytosolic nucleic acid sensing of viruses, their...
5.
Weindel C, Bell S, Vail K, West K, Patrick K, Watson R
Elife
. 2020 Feb;
9.
PMID: 32057291
The Parkinson's disease (PD)-associated gene leucine-rich repeat kinase 2 () has been studied extensively in the brain. However, several studies have established that mutations in confer susceptibility to mycobacterial infection,...
6.
West K, Scott H, Torres-Odio S, Phillip West A, Patrick K, Watson R
Cell Rep
. 2019 Nov;
29(6):1594-1609.e5.
PMID: 31693898
While transcriptional control of innate immune gene expression is well characterized, almost nothing is known about how pre-mRNA splicing decisions influence, or are influenced by, macrophage activation. Here, we demonstrate...