Kelly Kersten
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Explore the profile of Kelly Kersten including associated specialties, affiliations and a list of published articles.
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21
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4604
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Recent Articles
11.
Kersten K, Hu K, Combes A, Samad B, Harwin T, Ray A, et al.
Cancer Cell
. 2022 May;
40(6):624-638.e9.
PMID: 35623342
T cell exhaustion is a major impediment to antitumor immunity. However, it remains elusive how other immune cells in the tumor microenvironment (TME) contribute to this dysfunctional state. Here, we...
12.
Hu K, Eichorst J, McGinnis C, Patterson D, Chow E, Kersten K, et al.
Nat Methods
. 2020 Jul;
17(8):833-843.
PMID: 32632238
Spatial transcriptomics seeks to integrate single cell transcriptomic data within the three-dimensional space of multicellular biology. Current methods to correlate a cell's position with its transcriptome in living tissues have...
13.
Klarenbeek S, Doornebal C, Kas S, Bonzanni N, Bhin J, Braumuller T, et al.
Oncoimmunology
. 2020 Mar;
9(1):1724049.
PMID: 32117586
Effective treatment of invasive lobular carcinoma (ILC) of the breast is hampered by late detection, invasive growth, distant metastasis, and poor response to chemotherapy. Phosphoinositide 3-kinase (PI3K) signaling, one of...
14.
Binnewies M, Mujal A, Pollack J, Combes A, Hardison E, Barry K, et al.
Cell
. 2019 Apr;
177(3):556-571.e16.
PMID: 30955881
Differentiation of proinflammatory CD4 conventional T cells (T) is critical for productive antitumor responses yet their elicitation remains poorly understood. We comprehensively characterized myeloid cells in tumor draining lymph nodes...
15.
Salvagno C, Ciampricotti M, Tuit S, Hau C, van Weverwijk A, Coffelt S, et al.
Nat Cell Biol
. 2019 Mar;
21(4):511-521.
PMID: 30886344
Recent studies have revealed a role for macrophages and neutrophils in limiting chemotherapy efficacy; however, the mechanisms underlying the therapeutic benefit of myeloid-targeting agents in combination with chemotherapy are incompletely...
16.
Sobral-Leite M, Van de Vijver K, Michaut M, van der Linden R, Hooijer G, Horlings H, et al.
Oncoimmunology
. 2018 Dec;
7(12):e1509820.
PMID: 30524905
To better understand the expression pattern of programmed death-ligand 1 (PD-L1) expression in different breast cancer types, we characterized PD-L1 expression in tumor and tumor-infiltrating immune cells, in relation to...
17.
Binnewies M, Roberts E, Kersten K, Chan V, Fearon D, Merad M, et al.
Nat Med
. 2018 Apr;
24(5):541-550.
PMID: 29686425
The clinical successes in immunotherapy have been both astounding and at the same time unsatisfactory. Countless patients with varied tumor types have seen pronounced clinical response with immunotherapeutic intervention; however,...
18.
Kersten K, Coffelt S, Hoogstraat M, Verstegen N, Vrijland K, Ciampricotti M, et al.
Oncoimmunology
. 2017 Sep;
6(8):e1334744.
PMID: 28919995
Patients with primary solid malignancies frequently exhibit signs of systemic inflammation. Notably, elevated levels of neutrophils and their associated soluble mediators are regularly observed in cancer patients, and correlate with...
19.
Kersten K, de Visser K, van Miltenburg M, Jonkers J
EMBO Mol Med
. 2016 Dec;
9(2):137-153.
PMID: 28028012
Genetically engineered mouse models (GEMMs) have contributed significantly to the field of cancer research. In contrast to cancer cell inoculation models, GEMMs develop de novo tumors in a natural immune-proficient...
20.
Kersten K, Salvagno C, de Visser K
Front Immunol
. 2015 Oct;
6:516.
PMID: 26500653
Cancer immunotherapy is gaining momentum in the clinic. The current challenge is to understand why a proportion of cancer patients do not respond to cancer immunotherapy, and how this can...