Kelly E Beazley
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Explore the profile of Kelly E Beazley including associated specialties, affiliations and a list of published articles.
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18
Citations
186
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Recent Articles
1.
Kubilus J, Beazley K, Talbot C, Linsenmayer T
Exp Eye Res
. 2016 Feb;
145:337-340.
PMID: 26880020
Corneal epithelial (CE) cells are exposed to environmental insults (e.g., UV-irradiation), yet they suffer little damage. Our previous studies suggest that chicken CE cells have a novel form of protection...
2.
Beazley K, Nurminsky D, Lima F, Gandhi C, Nurminskaya M
Arterioscler Thromb Vasc Biol
. 2015 Jan;
35(3):573-9.
PMID: 25614285
Objective: Phenotypic plasticity of vascular smooth muscle cells (VSMCs) contributes to cardiovascular disease. Chondrocyte-like transformation of VSMCs associates with vascular calcification and underlies the formation of aortic cartilaginous metaplasia induced...
3.
Nurminskaya M, Beazley K, Smith E, Belkin A
J Vasc Res
. 2015 Jan;
51(6):418-28.
PMID: 25612735
Background: Phenotypic switch of vascular smooth muscle cells (VSMCs) accompanies neointima formation and associates with vascular diseases. Platelet-derived growth factor (PDGF)-induced activation of PDGFR/Akt1 and β-catenin signaling pathways in VSMCs...
4.
Beazley K, Nurminskaya M
Reprod Fertil Dev
. 2015 Jan;
28(7):974-981.
PMID: 25557047
Use of the dietary supplement quercetin is on the rise. Because previous studies imply an inhibitory effect of quercetin on male fertility, we explored the effects of this flavonoid on...
5.
Beazley K, Nurminskaya M
Biotechnol Lett
. 2014 Jun;
36(9):1901-7.
PMID: 24930093
Transglutaminase 2 (TG2) was used to attach biologically-active BMP2 to collagen type I-coated poly-L-lactic acid (PLLA) nanofibrous scaffolds. Irreversibly cross-linked BMP2 retained its activity and induced Smad-dependent gene expression in...
6.
Beazley K, Lima F, Borras T, Nurminskaya M
PLoS One
. 2013 Oct;
8(9):e76210.
PMID: 24098781
Rationale: Cartilaginous metaplasia of vascular smooth muscle (VSM) is characteristic for arterial calcification in diabetes and uremia and in the background of genetic alterations in matrix Gla protein (MGP). A...
7.
Beazley K, Reckard S, Nurminsky D, Lima F, Nurminskaya M
J Biol Chem
. 2013 Sep;
288(43):31400-8.
PMID: 24036114
Mutations in matrix Gla protein (MGP) have been correlated with vascular calcification. In the mouse model, MGP null vascular disease presents as calcifying cartilaginous lesions and mineral deposition along elastin...
8.
Niger C, Beazley K, Nurminskaya M
Biotechnol Lett
. 2013 Jul;
35(12):2193-9.
PMID: 23892982
Transglutaminase-mediated cross-linking has been employed to optimize the mechanical properties and stability of tissue scaffolds. We have characterized tissue transglutaminase (TG2)-mediated cross-linking as a useful tool to deliver biologically-active TGF...
9.
Beazley K, Eghtesad S, Nurminskaya M
J Biol Chem
. 2012 Dec;
288(4):2632-40.
PMID: 23223575
Warfarin can stimulate vascular calcification in vitro via activation of β-catenin signaling and/or inhibition of matrix Gla protein (MGP) carboxylation. Calcification was induced in vascular smooth muscle cells (VSMCs) with...
10.
Beazley K, Banyard D, Lima F, Deasey S, Nurminsky D, Konoplyannikov M, et al.
Arterioscler Thromb Vasc Biol
. 2012 Nov;
33(1):43-51.
PMID: 23117658
Objective: In vitro, transglutaminase-2 (TG2)-mediated activation of the β-catenin signaling pathway is central in warfarin-induced calcification, warranting inquiry into the importance of this signaling axis as a target for preventive...