Kelli Harmon
Overview
Explore the profile of Kelli Harmon including associated specialties, affiliations and a list of published articles.
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20
Citations
812
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Recent Articles
1.
Levinsky N, Mallela J, Opoka A, Harmon K, Lewis H, Zingarelli B, et al.
FASEB J
. 2019 Oct;
33(12):13660-13668.
PMID: 31593636
Olfactomedin-4 (OLFM4) identifies a subset of neutrophils conserved in both mouse and man, associated with worse outcomes in several inflammatory conditions. We investigated the role of OLFM4-positive neutrophils in murine...
2.
Bhowmick M, Tokmina-Roszyk D, Onwuha-Ekpete L, Harmon K, Robichaud T, Fuerst R, et al.
J Med Chem
. 2017 Apr;
60(9):3814-3827.
PMID: 28394608
The design of selective matrix metalloproteinase (MMP) inhibitors that also possess favorable solubility properties has proved to be especially challenging. A prior approach using collagen-model templates combined with transition state...
3.
Ganatra H, Varisco B, Harmon K, Lahni P, Opoka A, Wong H
Innate Immun
. 2016 Nov;
23(1):67-76.
PMID: 27821649
Children with severe sepsis are known to have altered zinc homeostasis and decreased circulating zinc levels, suggesting a role for zinc supplementation to improve outcomes. We tested the hypothesis that...
4.
Wong H, Cvijanovich N, Anas N, Allen G, Thomas N, Bigham M, et al.
Crit Care Med
. 2016 Aug;
44(11):2010-2017.
PMID: 27513537
Objective: The Pediatric Sepsis Biomarker Risk Model (PERSEVERE), a pediatric sepsis risk model, uses biomarkers to estimate baseline mortality risk for pediatric septic shock. It is unknown how PERSEVERE performs...
5.
Atkinson S, Varisco B, Sandquist M, Daly M, Klingbeil L, Kuethe J, et al.
Mol Med
. 2016 Aug;
22:455-463.
PMID: 27506554
Genetic ablation or pharmacologic inhibition of matrix metalloproteinase-8 () improves survival in an adult murine sepsis model. Because developmental age influences the host inflammatory response, we hypothesized that developmental age...
6.
Wong H, Cvijanovich N, Anas N, Allen G, Thomas N, Bigham M, et al.
EBioMedicine
. 2016 Feb;
2(12):2087-93.
PMID: 26844289
The temporal version of the pediatric sepsis biomarker risk model (tPERSEVERE) estimates the risk of a complicated course in children with septic shock based on biomarker changes from days 1...
7.
Atkinson S, Nolan M, Klingbeil L, Harmon K, Lahni P, Zingarelli B, et al.
Crit Care Med
. 2015 Oct;
44(4):e200-6.
PMID: 26496446
Objective: Inhibition of matrix metalloproteinase-8 improves survival following cecal ligation and puncture in mice, making it a potential therapeutic target. In the current study, we expand our understanding of the...
8.
Grunwell J, Weiss S, Cvijanovich N, Allen G, Thomas N, Freishtat R, et al.
Crit Care
. 2015 Sep;
19:327.
PMID: 26376786
Introduction: Experimental data from animal models of sepsis support a role for a transcription factor, nuclear erythroid-related factor 2 p45-related factor 2 (Nrf2), as a master regulator of antioxidant and...
9.
Wong H, Cvijanovich N, Anas N, Allen G, Thomas N, Bigham M, et al.
Crit Care Med
. 2015 May;
43(8):1646-53.
PMID: 25962083
Objective: The development of acute kidney injury in patients with sepsis is associated with worse outcomes. Identifying those at risk for septic acute kidney injury could help to inform clinical...
10.
Wong H, Cvijanovich N, Anas N, Allen G, Thomas N, Bigham M, et al.
Am J Respir Crit Care Med
. 2014 Dec;
191(3):309-15.
PMID: 25489881
Rationale: Using microarray data, we previously identified gene expression-based subclasses of septic shock with important phenotypic differences. The subclass-defining genes correspond to adaptive immunity and glucocorticoid receptor signaling. Identifying the...