Keith R Matthews
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Explore the profile of Keith R Matthews including associated specialties, affiliations and a list of published articles.
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78
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1824
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Recent Articles
11.
Cayla M, Nievas Y, Matthews K, Mottram J
Trends Parasitol
. 2022 Sep;
38(11):950-961.
PMID: 36075845
Trypanosomatid parasitic protozoa are divergent from opisthokont models and have evolved unique mechanisms to regulate their complex life cycles and to adapt to a range of hosts. Understanding how these...
12.
Tettey M, Rojas F, Matthews K
Nat Commun
. 2022 Jun;
13(1):3322.
PMID: 35680928
Trypanosomes causing African sleeping sickness use quorum-sensing (QS) to generate transmission-competent stumpy forms in mammalian hosts. This density-dependent process is signalled by oligopeptides that stimulate the signal transduction pathway leading...
13.
Contreras Garcia M, Walshe E, Steketee P, Paxton E, Lopez-Vidal J, Pearce M, et al.
Front Vet Sci
. 2022 Apr;
9:868912.
PMID: 35450136
Animal trypanosomiasis (AT) is a significant livestock disease, affecting millions of animals across Sub-Saharan Africa, Central and South America, and Asia, and is caused by the protozoan parasites , with...
14.
Oldrieve G, Malacart B, Lopez-Vidal J, Matthews K
Biol Open
. 2022 Apr;
11(4).
PMID: 35373253
Trypanosoma theileri, a non-pathogenic parasite of bovines, has a predicted surface protein architecture that likely aids survival in its mammalian host. Their surface proteins are encoded by genes which account...
15.
Matthews K, Larcombe S
Elife
. 2022 Feb;
11.
PMID: 35103595
Schuster et al. make the important observation that small numbers of trypanosomes can infect tsetse flies, and further argue that this can occur whether the infecting parasites are developmentally 'slender'...
16.
Venter F, Matthews K, Silvester E
Proc Biol Sci
. 2022 Jan;
289(1967):20212155.
PMID: 35042410
Laboratory studies of pathogens aim to limit complexity in order to disentangle the important parameters contributing to an infection. However, pathogens rarely exist in isolation, and hosts may sustain co-infections...
17.
Briggs E, Rojas F, McCulloch R, Matthews K, Otto T
Nat Commun
. 2021 Sep;
12(1):5268.
PMID: 34489460
Developmental steps in the trypanosome life-cycle involve transition between replicative and non-replicative forms specialised for survival in, and transmission between, mammalian and tsetse fly hosts. Here, using oligopeptide-induced differentiation in...
18.
Staneva D, Carloni R, Auchynnikava T, Tong P, Rappsilber J, Jeyaprakash A, et al.
Genome Res
. 2021 Aug;
31(11):2138-2154.
PMID: 34407985
Nucleosomes composed of histones are the fundamental units around which DNA is wrapped to form chromatin. Transcriptionally active euchromatin or repressive heterochromatin is regulated in part by the addition or...
19.
Oldrieve G, Verney M, Jaron K, Hebert L, Matthews K
Microb Genom
. 2021 Aug;
7(8).
PMID: 34397347
and are animal infective trypanosomes conventionally classified by their clinical disease presentation, mode of transmission, host range, kinetoplast DNA (kDNA) composition and geographical distribution. Unlike other members of the subgenus...
20.
Matthews K
Annu Rev Microbiol
. 2021 Aug;
75:495-514.
PMID: 34348028
African trypanosomes are responsible for important diseases of humans and animals in sub-Saharan Africa. The best-studied species is , which is characterized by development in the mammalian host between morphologically...