Keith R Matthews
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Explore the profile of Keith R Matthews including associated specialties, affiliations and a list of published articles.
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78
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1824
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Recent Articles
1.
Laidlaw R, Briggs E, Matthews K, Madany Mamlouk A, McCulloch R, Otto T
Bioinformatics
. 2025 Mar;
41(3).
PMID: 40065693
Motivation: Single-cell transcriptomics sequencing is used to compare different biological processes. However, often, those processes are asymmetric which are difficult to integrate. Current approaches often rely on integrating samples from...
2.
Rabuffo C, Schmidt M, Yadav P, Tong P, Carloni R, Barcons-Simon A, et al.
Nat Commun
. 2024 Dec;
15(1):10716.
PMID: 39715762
The eukaryotic nucleus exhibits a highly organized 3D genome architecture, with RNA transcription and processing confined to specific nuclear structures. While intra-chromosomal interactions, such as promoter-enhancer dynamics, are well-studied, the...
3.
Oldrieve G, Venter F, Cayla M, Verney M, Hebert L, Geerts M, et al.
Nat Commun
. 2024 Dec;
15(1):10485.
PMID: 39622840
African trypanosomes are important parasites in sub-Saharan Africa that undergo a quorum-sensing dependent development to morphologically 'stumpy forms' in mammalian hosts to favour transmission by tsetse flies. However, some trypanosome...
4.
Cayla M, Spanos C, McWilliam K, Waskett E, Rappsilber J, Matthews K
Nat Commun
. 2024 Apr;
15(1):2972.
PMID: 38582942
Adaptation to a change of environment is an essential process for survival, in particular for parasitic organisms exposed to a wide range of hosts. Such adaptations include rapid control of...
5.
Silvester E, Szoor B, Ivens A, Awuah-Mensah G, Gadelha C, Wickstead B, et al.
PLoS Pathog
. 2024 Feb;
20(2):e1011889.
PMID: 38408115
Trypanosomatid parasites undergo developmental regulation to adapt to the different environments encountered during their life cycle. In Trypanosoma brucei, a genome wide selectional screen previously identified a regulator of the...
6.
Saldanha I, Betson M, Vrettou C, Paxton E, Nixon J, Tennant P, et al.
Sci Rep
. 2024 Feb;
14(1):4158.
PMID: 38378867
Animal African trypanosomiasis (AAT) is a significant food security and economic burden in sub-Saharan Africa. Current AAT empirical and immunodiagnostic surveillance tools suffer from poor sensitivity and specificity, with blood...
7.
Larcombe S, Briggs E, Savill N, Szoor B, Matthews K
Proc Natl Acad Sci U S A
. 2023 Oct;
120(42):e2306848120.
PMID: 37824530
The development of in its mammalian host is marked by a distinct morphological change as replicative "slender" forms differentiate into cell cycle arrested "stumpy" forms in a quorum-sensing-dependent manner. Although...
8.
Briggs E, Marques C, Oldrieve G, Hu J, Otto T, Matthews K
Elife
. 2023 May;
12.
PMID: 37166108
African trypanosomes proliferate as bloodstream forms (BSFs) and procyclic forms in the mammal and tsetse fly midgut, respectively. This allows them to colonise the host environment upon infection and ensure...
9.
Morrison L, Steketee P, Tettey M, Matthews K
Virulence
. 2022 Nov;
14(1):2150445.
PMID: 36419235
African trypanosomes are vector-borne protozoa, which cause significant human and animal disease across sub-Saharan Africa, and animal disease across Asia and South America. In humans, infection is caused by variants...
10.
Staneva D, Bresson S, Auchynnikava T, Spanos C, Rappsilber J, Jeyaprakash A, et al.
Elife
. 2022 Sep;
11.
PMID: 36169304
Kinetoplastids are a highly divergent lineage of eukaryotes with unusual mechanisms for regulating gene expression. We previously surveyed 65 putative chromatin factors in the kinetoplastid . Our analyses revealed that...