Keith R Humphries
Overview
Explore the profile of Keith R Humphries including associated specialties, affiliations and a list of published articles.
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Articles
4
Citations
94
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0
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Recent Articles
1.
Gasparetto M, Pei S, Minhajuddin M, Khan N, Pollyea D, Myers J, et al.
Haematologica
. 2017 Mar;
102(6):1054-1065.
PMID: 28280079
Aldehyde dehydrogenase 1A1 (ALDH1A1) activity is high in hematopoietic stem cells and functions in part to protect stem cells from reactive aldehydes and other toxic compounds. In contrast, we found...
2.
Cusan M, Vegi N, Mulaw M, Bamezai S, Kaiser L, Deshpande A, et al.
Blood
. 2016 Nov;
129(3):319-323.
PMID: 27827825
There is high interest in understanding the mechanisms that drive self-renewal of stem cells. HOXB4 is one of the few transcription factors that can amplify long-term repopulating hematopoietic stem cells...
3.
Reindl C, Quentmeier H, Petropoulos K, Greif P, Benthaus T, Argiropoulos B, et al.
Clin Cancer Res
. 2009 Mar;
15(7):2238-47.
PMID: 19276253
Purpose: CBL is a negative regulator of activated receptor tyrosine kinases (RTK). In this study, we determined the frequency of CBL mutations in acute leukemias and evaluated the oncogenic potential...
4.
Beslu N, Krosl J, Laurin M, Mayotte N, Humphries K, Sauvageau G
Blood
. 2004 Jul;
104(8):2307-14.
PMID: 15226173
HOXB4 overexpression induces unique in vivo and in vitro expansion of hemopoietic stem cells (HSCs) without causing leukemia. Very little is known about the molecular basis underlying HOXB4-induced HSC self-renewal....