Keith A Breau
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Explore the profile of Keith A Breau including associated specialties, affiliations and a list of published articles.
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10
Citations
145
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Recent Articles
1.
Cotton M, Ariel P, Chen K, Walcott V, Dixit M, Breau K, et al.
Sci Rep
. 2024 Jul;
14(1):15195.
PMID: 38956443
The intestinal epithelium dynamically controls cell cycle, yet no experimental platform exists for directly analyzing cell cycle phases in non-immortalized human intestinal epithelial cells (IECs). Here, we present two reporters...
2.
Breau K
Cell Mol Gastroenterol Hepatol
. 2024 Feb;
17(5):879-880.
PMID: 38403274
No abstract available.
3.
An in vitro platform for quantifying cell cycle phase lengths in primary human intestinal stem cells
Cotton M, Ariel P, Chen K, Walcott V, Dixit M, Breau K, et al.
bioRxiv
. 2023 Oct;
PMID: 37873351
Background And Aims: The intestinal epithelium exhibits dynamic control of cell cycle phase lengths, yet no experimental platform exists for directly analyzing cell cycle phases in living human intestinal stem...
4.
Rivera K, Bliton R, Burclaff J, Czerwinski M, Liu J, Trueblood J, et al.
Cell Mol Gastroenterol Hepatol
. 2023 Aug;
16(5):823-846.
PMID: 37562653
Background And Aims: Hypoxia in the intestinal epithelium can be caused by acute ischemic events or chronic inflammation in which immune cell infiltration produces inflammatory hypoxia starving the mucosa of...
5.
Rivera K, Bliton R, Burclaff J, Czerwinski M, Liu J, Trueblood J, et al.
bioRxiv
. 2023 Feb;
PMID: 36778265
Background & Aims: Hypoxia in the intestinal epithelium can be caused by acute ischemic events or conditions like Inflammatory Bowel Disease (IBD) where immune cell infiltration produces 'inflammatory hypoxia', a...
6.
Ok M, Liu J, Bliton R, Hinesley C, San Pedro E, Breau K, et al.
Am J Physiol Gastrointest Liver Physiol
. 2023 Feb;
324(4):G262-G280.
PMID: 36749911
() toxins A (TcdA) and B (TcdB) cause antibiotic-associated colitis in part by disrupting epithelial barrier function. Accurate in vitro models are necessary to detect early toxicity kinetics, investigate disease...
7.
Breau K, Ok M, Gomez-Martinez I, Burclaff J, Kohn N, Magness S
Stem Cell Reports
. 2022 May;
17(6):1493-1506.
PMID: 35523179
Two-dimensional (2D) cultures of intestinal and colonic epithelium can be generated using human intestinal stem cells (hISCs) derived from primary tissue sources. These 2D cultures are emerging as attractive and...
8.
Gomez-Martinez I, Bliton R, Breau K, Czerwinski M, Williamson I, Wen J, et al.
Cell Mol Gastroenterol Hepatol
. 2022 Apr;
14(2):409-434.
PMID: 35489715
Background & Aims: Fatty acid oxidation by absorptive enterocytes has been linked to the pathophysiology of type 2 diabetes, obesity, and dyslipidemia. Caco-2 and organoids have been used to study...
9.
Burclaff J, Bliton R, Breau K, Ok M, Gomez-Martinez I, Ranek J, et al.
Cell Mol Gastroenterol Hepatol
. 2022 Feb;
13(5):1554-1589.
PMID: 35176508
Background & Aims: Single-cell transcriptomics offer unprecedented resolution of tissue function at the cellular level, yet studies analyzing healthy adult human small intestine and colon are sparse. Here, we present...
10.
Cousin M, Creighton B, Breau K, Spillmann R, Torti E, Dontu S, et al.
Nat Genet
. 2021 Jul;
53(7):1006-1021.
PMID: 34211179
SPTBN1 encodes βII-spectrin, the ubiquitously expressed β-spectrin that forms micrometer-scale networks associated with plasma membranes. Mice deficient in neuronal βII-spectrin have defects in cortical organization, developmental delay and behavioral deficiencies....