Keiichi Izumikawa
Overview
Explore the profile of Keiichi Izumikawa including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
730
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0
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Recent Articles
1.
Ogawa A, Izumikawa K, Tate S, Isoyama S, Mori M, Fujiwara K, et al.
Mol Cell
. 2025 Feb;
85(5):894-912.e10.
PMID: 39909041
Impairment of ribosome biogenesis (RiBi) triggered by inhibition of ribosomal RNA (rRNA) synthesis and processing leads to various biological effects. We report that Schlafen 11 (SLFN11) induces TP53-independent apoptosis through...
2.
Hirooka Y, Izumikawa K, Miyao S, Ohga T, Nobe Y, Taoka M, et al.
Biochem Biophys Res Commun
. 2024 Dec;
744:151175.
PMID: 39706051
WD repeat domain 74 (WDR74) is a nucleolar protein involved in the early stages of pre-60S maturation in the ribosome biogenesis pathway. In later stages, WDR74 interacts with MTR4, an...
3.
Singh V, Itoh Y, DelOlio S, Hassan A, Naschberger A, Flygaard R, et al.
Nat Commun
. 2024 May;
15(1):4272.
PMID: 38769321
The mitoribosome translates mitochondrial mRNAs and regulates energy conversion that is a signature of aerobic life forms. We present a 2.2 Å resolution structure of human mitoribosome together with validated...
4.
Singh V, Itoh Y, DelOlio S, Hassan A, Naschberger A, Flygaard R, et al.
bioRxiv
. 2023 Jul;
PMID: 37503168
The mitoribosome translates mitochondrial mRNAs and regulates energy conversion that is a signature of aerobic life forms. We present a 2.2 Å resolution structure of human mitoribosome together with validated...
5.
Egawa N, Izumi Y, Suzuki H, Tsuge I, Fujita K, Shimano H, et al.
Sci Rep
. 2022 May;
12(1):7988.
PMID: 35568729
Dyslipidemia is considered an essential component of the pathological process of amyotrophic lateral sclerosis (ALS), a fatal motor neuron disease. Although TAR DNA Binding Protein 43 kDa (TDP-43) links both...
6.
Izumikawa K, Ishikawa H, Yoshikawa H, Fujiyama S, Watanabe A, Aburatani H, et al.
Nucleic Acids Res
. 2019 Sep;
47(19):10357-10372.
PMID: 31504794
Activation of ribosomal RNA (rRNA) synthesis is pivotal during cell growth and proliferation, but its aberrant upregulation may promote tumorigenesis. Here, we demonstrate that the candidate oncoprotein, LYAR, enhances ribosomal...
7.
Izumikawa K, Nobe Y, Ishikawa H, Yamauchi Y, Taoka M, Sato K, et al.
Nucleic Acids Res
. 2019 Feb;
47(5):2487-2505.
PMID: 30759234
TDP-43 regulates cellular levels of Cajal bodies (CBs) that provide platforms for the assembly and RNA modifications of small nuclear ribonucleoproteins (snRNPs) involved in pre-mRNA splicing. Alterations in these snRNPs...
8.
Chen M, Xu R, Rai A, Suwakulsiri W, Izumikawa K, Ishikawa H, et al.
PLoS One
. 2019 Jan;
14(1):e0210003.
PMID: 30608951
Extracellular vesicle (EV) microRNAs are of major interest as potential diagnostic biomarkers in all cancer types. This study aims to identify miRNA profiles of shed microvesicles (sMVs) and exosomes (Exos)...
9.
Taoka M, Nobe Y, Yamaki Y, Sato K, Ishikawa H, Izumikawa K, et al.
Nucleic Acids Res
. 2018 Sep;
46(18):9289-9298.
PMID: 30202881
During ribosome biogenesis, ribosomal RNAs acquire various chemical modifications that ensure the fidelity of translation, and dysregulation of the modification processes can cause proteome changes as observed in cancer and...
10.
Izumikawa K, Ishikawa H, Simpson R, Takahashi N
RNA Biol
. 2018 Apr;
15(7):849-855.
PMID: 29683372
Chtop binds competitively to the arginine methyltransferases PRMT1 and PRMT5, thereby promoting the asymmetric or symmetric methylation of arginine residues, respectively. In cooperation with PRMT1, Chtop activates transcription of certain...