Kazuhiro Maeshima
Overview
Explore the profile of Kazuhiro Maeshima including associated specialties, affiliations and a list of published articles.
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Articles
79
Citations
3632
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Recent Articles
21.
Maeshima K, Iida S, Tamura S
Cold Spring Harb Perspect Biol
. 2021 Apr;
13(5).
PMID: 33820775
Genomic information is encoded on long strands of DNA, which are folded into chromatin and stored in a tiny nucleus. Nuclear chromatin is a negatively charged polymer composed of DNA,...
22.
Itoh Y, Iida S, Tamura S, Nagashima R, Shiraki K, Goto T, et al.
Life Sci Alliance
. 2021 Feb;
4(4).
PMID: 33536240
Liquid droplets formed inside the cell by liquid-liquid phase separation maintain membrane-less condensates/bodies (or compartments). These droplets are important for concentrating certain molecules and facilitating spatiotemporal regulation of cellular functions....
23.
Ide S, Imai R, Ochi H, Maeshima K
Sci Adv
. 2020 Oct;
6(42).
PMID: 33055158
The nucleolus is a nuclear body with multiphase liquid droplets for ribosomal RNA (rRNA) transcription. How rRNA transcription is regulated in the droplets remains unclear. Here, using single-molecule tracking of...
24.
Maeshima K, Tamura S, Hansen J, Itoh Y
Curr Opin Cell Biol
. 2020 Apr;
64:77-89.
PMID: 32283330
Eukaryotic chromatin is a negatively charged polymer consisting of genomic DNA, histones, and various nonhistone proteins. Because of its highly charged character, the structure of chromatin varies greatly depending on...
25.
Ashwin S, Maeshima K, Sasai M
Biophys Rev
. 2020 Mar;
12(2):461-468.
PMID: 32206982
Eukaryotic chromatin is a complex of genome DNA and associated proteins, and its structure and dynamics play a crucial role in regulating DNA functions. Chromatin takes rather irregular structures in...
26.
Babokhov M, Hibino K, Itoh Y, Maeshima K
J Mol Biol
. 2019 Nov;
432(3):694-700.
PMID: 31689435
Eukaryotic chromatin is a complex of nucleic acids and proteins that is central to interpreting the information coded in the genome. Chromatin is rather irregularly folded inside the nucleus in...
27.
Ashwin S, Nozaki T, Maeshima K, Sasai M
Proc Natl Acad Sci U S A
. 2019 Sep;
116(40):19939-19944.
PMID: 31527274
Understanding chromatin organization and dynamics is important, since they crucially affect DNA functions. In this study, we investigate chromatin dynamics by statistically analyzing single-nucleosome movement in living human cells. Bimodal...
28.
Prieto E, Maeshima K
Essays Biochem
. 2019 Apr;
63(1):133-145.
PMID: 30967477
The organization and regulation of genomic DNA as nuclear chromatin is necessary for proper DNA function inside living eukaryotic cells. While this has been extensively explored, no true consensus is...
29.
Maeshima K, Ide S, Babokhov M
Curr Opin Cell Biol
. 2019 Mar;
58:95-104.
PMID: 30908980
Chromatin in eukaryotic cells is a negatively charged polymer composed of DNA, histones, and various associated proteins. Over the past ten years, our view of chromatin has shifted from a...
30.
Nagashima R, Hibino K, Ashwin S, Babokhov M, Fujishiro S, Imai R, et al.
J Cell Biol
. 2019 Mar;
218(5):1511-1530.
PMID: 30824489
Although chromatin organization and dynamics play a critical role in gene transcription, how they interplay remains unclear. To approach this issue, we investigated genome-wide chromatin behavior under various transcriptional conditions...