Kazuhide Ayajiki
Overview
Explore the profile of Kazuhide Ayajiki including associated specialties, affiliations and a list of published articles.
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41
Citations
491
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Recent Articles
1.
Ito S, Ohno Y, Tanaka T, Kobuchi S, Ayajiki K, Manabe E, et al.
Ren Fail
. 2019 Apr;
41(1):284-293.
PMID: 31014150
Objective: We investigate the mechanism of neutrophil/lymphocyte ratio (NLR) elevation, a useful prognostic marker in patients with cardiovascular diseases (CVDs). Methods: In this clinical study, we retrospectively searched for factors...
2.
Kobuchi S, Miura K, Iwao H, Ayajiki K
Eur J Pharmacol
. 2015 May;
762:26-34.
PMID: 25962662
Vasodilators, such as prostacyclin, nitric oxide (NO), and endothelium-derived hyperpolarizing factor (EDHF), released from the vascular endothelium are important in the maintenance of systemic blood pressure. Some studies have shown...
3.
Kobuchi S, Tanaka R, Shintani T, Suzuki R, Tsutsui H, Ohkita M, et al.
Clin Exp Pharmacol Physiol
. 2014 Dec;
42(3):278-86.
PMID: 25482107
Excitation of the renal sympathetic nervous system is important for the development of ischaemic acute kidney injury (AKI) in rats. We reported that intravenous treatment with GABA has preventive effects...
4.
Toda N, Ayajiki K, Okamura T
Curr Alzheimer Res
. 2014 Sep;
11(8):733-44.
PMID: 25212912
Increasing evidence supports the idea that chronic hypoperfusion in the brain is responsible for the pathogenesis underling Alzheimer's disease (AD). Obesity at midlife is associated with the risk of cognitive...
5.
Kobuchi S, Tanaka R, Funai A, Suzuki R, Yazawa M, Tsutsui H, et al.
J Cardiovasc Pharmacol
. 2013 Oct;
63(1):9-15.
PMID: 24084211
Time-dependent changes in the renal sympathetic nerve activity (RSNA) in the progression of chronic kidney disease (CKD) have not been investigated, despite the fact that renal sympathetic nervous system is...
6.
Toda N, Ayajiki K, Okamura T
J Cardiovasc Pharmacol
. 2012 Mar;
60(1):100-8.
PMID: 22407338
Blood flow in oral tissues, including the tongue, salivary glands, gingiva, dental pulp, and lip, plays an important role in modulating the complex oral functions involved in food intake. Oral...
7.
Ayajiki K, Kobuchi S, Tawa M, Okamura T
Hypertens Res
. 2011 Oct;
35(1):88-92.
PMID: 21975516
The functional roles of the nitrergic nerves innervating the monkey cerebral artery were evaluated in a tension-response study examining isolated arteries in vitro and cerebral angiography in vivo. Nicotine produced...
8.
Kobuchi S, Tanaka R, Shintani T, Suzuki R, Tsutsui H, Ohkita M, et al.
J Pharmacol Exp Ther
. 2011 Jun;
338(3):767-74.
PMID: 21632868
The excitation of the renal sympathetic nervous system plays an important role in the development of ischemic acute kidney injury (AKI) in rats. We have reported that intravenous treatment with...
9.
Tawa M, Yamamizu K, Geddawy A, Shimosato T, Imamura T, Ayajiki K, et al.
J Pharmacol Sci
. 2011 May;
116(2):188-96.
PMID: 21597236
To investigate the effect of hypoxia or hypoxia/reoxygenation on vascular smooth muscle function, mechanical response of monkey coronary artery without endothelium was studied under normoxia, hypoxia, and hypoxia/reoxygenation. Hypoxia or...
10.
Tawa M, Fukumoto T, Ohkita M, Yamashita N, Geddawy A, Imamura T, et al.
J Cardiovasc Pharmacol
. 2011 Feb;
57(5):575-8.
PMID: 21326108
We have recently shown that an appropriate amount of exogenous big endothelin-1 (ET-1) has beneficial effects on ischemia-/reperfusion-induced norepinephrine overflow and cardiac dysfunction in rat hearts and that these effects...