Kay L Medina
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Explore the profile of Kay L Medina including associated specialties, affiliations and a list of published articles.
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36
Citations
1443
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Recent Articles
1.
Welch B, Parikh S, Kay N, Medina K
Res Sq
. 2024 Oct;
PMID: 39399662
Chronic lymphocytic leukemia (CLL) patients are immunocompromised and highly vulnerable to serious recurrent infections. Conventional dendritic cells (cDCs) and plasmacytoid DCs (pDCs) are principal sensors of infection and are essential...
2.
Welch B, Manso B, Gwin K, Lothert P, Parikh S, Kay N, et al.
Front Oncol
. 2023 Dec;
13:1302038.
PMID: 38111528
Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of CD19 CD5 clonal B lymphocytes in the blood, bone marrow, and peripheral lymphoid organs. Treatment options for patients range from...
3.
Medina K
Int J Mol Sci
. 2022 Jul;
23(13).
PMID: 35806293
The Class III receptor tyrosine kinase Flt3 and its ligand, the Flt3-ligand (FL), play an integral role in regulating the proliferation, differentiation, and survival of multipotent hematopoietic and lymphoid progenitors...
4.
Lehrke M, Shapiro M, Rajcula M, Kennedy M, McCue S, Medina K, et al.
Elife
. 2021 Nov;
10.
PMID: 34762046
Iron-sulfur (Fe-S) clusters are cofactors essential for the activity of numerous enzymes including DNA polymerases, helicases, and glycosylases. They are synthesized in the mitochondria as Fe-S intermediates and are exported...
5.
Manso B, Medina K
STAR Protoc
. 2021 May;
2(2):100485.
PMID: 34041499
Transcription factor (TF) expression levels drive developmental programs, including cell fate and function, and their measurement by flow cytometry allows for robust downstream analysis. However, significant batch-to-batch variability between replicative...
6.
Manso B, Krull J, Gwin K, Lothert P, Welch B, Novak A, et al.
iScience
. 2021 Jan;
24(1):101994.
PMID: 33458625
TNFα is implicated in chronic lymphocytic leukemia (CLL) immunosuppression and disease progression. TNFα is constitutively produced by CLL B cells and is a negative regulator of bone marrow (BM) myelopoiesis....
7.
Schworer S, Becker F, Feller C, Baig A, Kober U, Henze H, et al.
Nature
. 2019 Aug;
572(7769):E11-E15.
PMID: 31363230
An Amendment to this paper has been published and can be accessed via a link at the top of the paper.
8.
Manso B, Zhang H, Mikkelson M, Gwin K, Secreto C, Ding W, et al.
Leukemia
. 2018 Oct;
33(3):638-652.
PMID: 30291337
The consequences of immune dysfunction in B-chronic lymphocytic leukemia (CLL) likely relate to the incidence of serious recurrent infections and second malignancies that plague CLL patients. The well-described immune abnormalities...
9.
Schworer S, Becker F, Feller C, Baig A, Kober U, Henze H, et al.
Nature
. 2016 Dec;
540(7633):428-432.
PMID: 27919074
The functionality of stem cells declines during ageing, and this decline contributes to ageing-associated impairments in tissue regeneration and function. Alterations in developmental pathways have been associated with declines in...
10.
Developmental stage-specific effects of Pim-1 dysregulation on murine bone marrow B cell development
Xu Z, Gwin K, Li Y, Medina K
BMC Immunol
. 2016 Jun;
17(1):16.
PMID: 27287229
Background: The serine threonine kinase Pim-1 has documented roles in hematopoietic progenitor and B cell precursor proliferation and survival. Pim-1 is a molecular target of the transcription factor Hoxa9. Previous...