Katsuzumi Okumura
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Explore the profile of Katsuzumi Okumura including associated specialties, affiliations and a list of published articles.
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48
Citations
890
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Recent Articles
1.
Zang L, Kagotani K, Hayakawa T, Tsuji T, Okumura K, Shimada Y, et al.
Molecules
. 2023 Dec;
28(24).
PMID: 38138517
Obesity is an emerging global health issue with an increasing risk of disease linked to lifestyle choices. Previously, we reported that the hexane extract of (CSHE) suppressed lipid accumulation in...
2.
Hayakawa T, Yamamoto A, Yoneda T, Hori S, Okochi N, Kagotani K, et al.
J Cell Sci
. 2022 Dec;
136(2).
PMID: 36546833
The temporal order of DNA replication along the chromosomes is thought to reflect the transcriptional competence of the genome. During differentiation of mouse 3T3-L1 cells into adipocytes, cells undergo one...
3.
Hayakawa T, Suzuki R, Kagotani K, Okumura K, Takebayashi S
Cytogenet Genome Res
. 2021 Nov;
161(8-9):437-444.
PMID: 34818230
E/L Repli-seq is a powerful tool for detecting cell type-specific replication landscapes in mammalian cells, but its potential to monitor DNA replication under replication stress awaits better understanding. Here, we...
4.
Takebayashi S, Ryba T, Wimbish K, Hayakawa T, Sakaue M, Kuriya K, et al.
Cells
. 2021 Feb;
10(2).
PMID: 33572832
Multiple epigenetic pathways underlie the temporal order of DNA replication (replication timing) in the contexts of development and disease. DNA methylation by DNA methyltransferases (Dnmts) and downstream chromatin reorganization and...
5.
Miura H, Takahashi S, Shibata T, Nagao K, Obuse C, Okumura K, et al.
Nat Protoc
. 2020 Nov;
15(12):4058-4100.
PMID: 33230331
Replication timing (RT) domains are stable units of chromosome structure that are regulated in the context of development and disease. Conventional genome-wide RT mapping methods require many S-phase cells for...
6.
Ikuno A, Akeda K, Takebayashi S, Shimaoka M, Okumura K, Sudo A
PLoS One
. 2019 Sep;
14(9):e0222188.
PMID: 31513634
Background: Environmental and endogenous factors under genetic predisposition are considered to initiate the human intervertebral disc (IVD) degeneration. DNA methylation is an essential mechanism to ensure cell-specific gene expression for...
7.
Okamura M, Yamanaka Y, Shigemoto M, Kitadani Y, Kobayashi Y, Kambe T, et al.
PLoS One
. 2019 Jul;
14(7):e0220511.
PMID: 31344122
[This corrects the article DOI: 10.1371/journal.pone.0197165.].
8.
Takahashi S, Miura H, Shibata T, Nagao K, Okumura K, Ogata M, et al.
Nat Genet
. 2019 Feb;
51(3):529-540.
PMID: 30804559
Here, we report a single-cell DNA replication sequencing method, scRepli-seq, a genome-wide methodology that measures copy number differences between replicated and unreplicated DNA. Using scRepli-seq, we demonstrate that replication-domain organization...
9.
Takebayashi S, Ogata S, Ogata M, Okumura K
Biosci Biotechnol Biochem
. 2018 Sep;
82(12):2098-2100.
PMID: 30198402
Here, we show that semiconductor-based sequencing technology can be used to map mammalian replication domains, chromosomal units with similar DNA replication timing. Replicating DNA purified from mammalian cells was successfully...
10.
Okamura M, Yamanaka Y, Shigemoto M, Kitadani Y, Kobayashi Y, Kambe T, et al.
PLoS One
. 2018 May;
13(5):e0197165.
PMID: 29746542
DBP5, also known as DDX19, GLE1 and inositol hexakisphosphate (IP6) function in messenger RNA (mRNA) export at the cytoplasmic surface of the nuclear pore complex in eukaryotic cells. DBP5 is...