Katrin Paeschke
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Explore the profile of Katrin Paeschke including associated specialties, affiliations and a list of published articles.
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51
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2464
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Recent Articles
1.
Fagunloye A, De Magis A, Little J, Contreras I, Dorwart T, Bonilla B, et al.
EMBO J
. 2025 Jan;
44(5):1512-1539.
PMID: 39838174
Homologous recombination (HR) is important for DNA damage tolerance during replication. The yeast Shu complex, a conserved homologous recombination factor, prevents replication-associated mutagenesis. Here we examine how yeast cells require...
2.
Schult P, Kummerer B, Hafner M, Paeschke K
Cell Host Microbe
. 2024 Aug;
32(9):1579-1593.e8.
PMID: 39094585
Viral genomes are enriched with G-quadruplexes (G4s), non-canonical structures formed in DNA or RNA upon assembly of four guanine stretches into stacked quartets. Because of their critical roles, G4s are...
3.
Schult P, Paeschke K
Methods Enzymol
. 2024 Mar;
695:29-43.
PMID: 38521589
G-quadruplexes (G4) are functionally important nucleic acid structures, involved in many cellular pathways. They are often dynamically regulated in cells, which makes detecting them in vivo challenging and dependent on...
4.
Chang Y, Bach L, Hasiuk M, Wen L, Elmzzahi T, Tsui C, et al.
Sci Immunol
. 2024 Mar;
9(93):eadd4818.
PMID: 38427718
T follicular helper (T) cells are essential for effective antibody responses, but deciphering the intrinsic wiring of mouse T cells has long been hampered by the lack of a reliable...
5.
Rosing S, Ullrich F, Meisterfeld S, Schmidt F, Mlitzko L, Croon M, et al.
Nat Commun
. 2024 Feb;
15(1):1534.
PMID: 38378748
Myotonic dystrophy type 2 (DM2) is a tetranucleotide CCTG repeat expansion disease associated with an increased prevalence of autoimmunity. Here, we identified an elevated type I interferon (IFN) signature in...
6.
Hersperger F, Meyring T, Weber P, Chhatbar C, Monaco G, Dionne M, et al.
Elife
. 2024 Jan;
12.
PMID: 38189792
Environmental factors, infection, or injury can cause oxidative stress in diverse tissues and loss of tissue homeostasis. Effective stress response cascades, conserved from invertebrates to mammals, ensure reestablishment of homeostasis...
7.
TMPRSS2 isoform 1 downregulation by G-quadruplex stabilization induces SARS-CoV-2 replication arrest
De Magis A, Schult P, Schonleber A, Linke R, Ludwig K, Kummerer B, et al.
BMC Biol
. 2024 Jan;
22(1):5.
PMID: 38185627
Background: SARS-CoV-2 infection depends on the host cell factors angiotensin-converting enzyme 2, ACE2, and the transmembrane serinprotease 2, TMPRSS2. Potential inhibitors of these proteins would be ideal targets against severe...
8.
Olschok K, Altenburg B, de Toledo M, Maurer A, Abels A, Beier F, et al.
Front Oncol
. 2023 Nov;
13:1277453.
PMID: 37941547
Imetelstat shows activity in patients with myeloproliferative neoplasms, including primary myelofibrosis (PMF) and essential thrombocythemia. Here, we describe a case of prolonged disease stabilization by imetelstat treatment of a high-risk...
9.
De Magis A, Limmer M, Mudiyam V, Monchaud D, Juranek S, Paeschke K
Nat Commun
. 2023 Oct;
14(1):6705.
PMID: 37872164
Senescence has two roles in oncology: it is known as a potent tumor-suppressive mechanism, which also supports tissue regeneration and repair, it is also known to contribute to reduced patient...
10.
A conserved isoleucine in the binding pocket of RIG-I controls immune tolerance to mitochondrial RNA
de Regt A, Anand K, Ciupka K, Bender F, Gatterdam K, Putschli B, et al.
Nucleic Acids Res
. 2023 Oct;
51(21):11893-11910.
PMID: 37831086
RIG-I is a cytosolic receptor of viral RNA essential for the immune response to numerous RNA viruses. Accordingly, RIG-I must sensitively detect viral RNA yet tolerate abundant self-RNA species. The...