Kathryn J A Steel
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Explore the profile of Kathryn J A Steel including associated specialties, affiliations and a list of published articles.
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13
Citations
1337
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Recent Articles
1.
Hughes C, Ryan S, Steel K, van den Beukel M, Trouw L, van Schie K, et al.
RMD Open
. 2023 Dec;
9(4).
PMID: 38123480
Objective: Undifferentiated, early inflammatory arthritis (EIA) can differentiate into seropositive or seronegative rheumatoid arthritis (RA), peripheral spondyloarthritis (SpA) or remain as seronegative undifferentiated inflammatory arthritis (UIA). Little is known about...
2.
Gray E, Srenathan U, Durham L, Lalnunhlimi S, Steel K, Catrina A, et al.
Clin Exp Immunol
. 2023 Jun;
214(1):103-119.
PMID: 37367825
IL-17A+ CD8+ T-cells, termed Tc17 cells, have been identified at sites of inflammation in several immune-mediated inflammatory diseases. However, the biological function of human IL-17A+ CD8+ T-cells is not well...
3.
Povoleri G, Durham L, Gray E, Lalnunhlimi S, Kannambath S, Pitcher M, et al.
Cell Rep
. 2023 May;
42(5):112514.
PMID: 37195862
CD69+CD103+ tissue-resident memory T (T) cells are important drivers of inflammation. To decipher their role in inflammatory arthritis, we apply single-cell, high-dimensional profiling to T cells from the joints of...
4.
Seow J, Graham C, Merrick B, Acors S, Pickering S, Steel K, et al.
Nat Microbiol
. 2020 Oct;
5(12):1598-1607.
PMID: 33106674
Antibody responses to SARS-CoV-2 can be detected in most infected individuals 10-15 d after the onset of COVID-19 symptoms. However, due to the recent emergence of SARS-CoV-2 in the human...
5.
Wells P, Doores K, Couvreur S, Martinez Nunez R, Seow J, Graham C, et al.
J Infect
. 2020 Oct;
81(6):931-936.
PMID: 33068628
Background: Understanding of the true asymptomatic rate of infection of SARS-CoV-2 is currently limited, as is understanding of the population-based seroprevalence after the first wave of COVID-19 within the UK....
6.
Pickering S, Betancor G, Galao R, Merrick B, Signell A, Wilson H, et al.
PLoS Pathog
. 2020 Sep;
16(9):e1008817.
PMID: 32970782
There is a clear requirement for an accurate SARS-CoV-2 antibody test, both as a complement to existing diagnostic capabilities and for determining community seroprevalence. We therefore evaluated the performance of...
7.
Ridley M, Fleskens V, Roberts C, Lalnunhlimi S, Alnesf A, OByrne A, et al.
J Immunol
. 2020 Apr;
204(11):2940-2948.
PMID: 32321757
The expression of anti-inflammatory IL-10 by CD4 T cells is indispensable for immune homeostasis, as it allows T cells to moderate their effector function. We previously showed that TNF-α blockade...
8.
Burns L, Maroof A, Marshall D, Steel K, Lalnunhlimi S, Cole S, et al.
Eur J Immunol
. 2019 Dec;
50(4):568-580.
PMID: 31850514
The pro-inflammatory cytokine IL-17A has been implicated in the immunopathology of inflammatory arthritis. IL-17F bears 50% homology to IL-17A and has recently been suggested to play a role in inflammation....
9.
Povoleri G, Lalnunhlimi S, Steel K, Agrawal S, OByrne A, Ridley M, et al.
Eur J Immunol
. 2019 Nov;
50(3):445-458.
PMID: 31722123
TNF-blockade has shown clear therapeutic value in rheumatoid arthritis and other immune-mediated inflammatory diseases, however its mechanism of action is not fully elucidated. We investigated the effects of TNF-blockade on...
10.
Steel K, Srenathan U, Ridley M, Durham L, Wu S, Ryan S, et al.
Arthritis Rheumatol
. 2019 Nov;
72(3):435-447.
PMID: 31677365
Objective: Genetic associations imply a role for CD8+ T cells and the interleukin-23 (IL-23)/IL-17 axis in psoriatic arthritis (PsA) and other spondyloarthritides (SpA). IL-17A+CD8+ (Tc17) T cells are enriched in...