Kathryn B Grandinetti
Overview
Explore the profile of Kathryn B Grandinetti including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
253
Followers
0
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Recent Articles
1.
Balasooriya E, Wu Q, Ellis H, Zhen Y, Norden B, Corcoran R, et al.
Clin Cancer Res
. 2024 Mar;
30(10):2181-2192.
PMID: 38437671
Purpose: FGFR2 and FGFR3 show oncogenic activation in many cancer types, often through chromosomal fusion or extracellular domain mutation. FGFR2 and FGFR3 alterations are most prevalent in intrahepatic cholangiocarcinoma (ICC)...
2.
Wood A, Krytska K, Ryles H, Infarinato N, Sano R, Hansel T, et al.
Clin Cancer Res
. 2016 Dec;
23(11):2856-2868.
PMID: 27986745
Anaplastic lymphoma kinase () is the most frequently mutated oncogene in the pediatric cancer neuroblastoma. We performed an screen for synergistic drug combinations that target neuroblastomas with mutations in to...
3.
Samaraweera L, Grandinetti K, Huang R, Spengler B, Ross R
BMC Cancer
. 2014 Jun;
14:309.
PMID: 24885481
Background: Neuroblastoma (NB) is the most common extracranial solid tumor in children. NB tumors and derived cell lines are phenotypically heterogeneous. Cell lines are classified by phenotype, each having distinct...
4.
Kim S, Dubrovska A, Salamone R, Walker J, Grandinetti K, Bonamy G, et al.
PLoS One
. 2013 Jan;
8(1):e51671.
PMID: 23300950
Emerging evidence suggests that some cancers contain a population of stem-like TICs (tumor-initiating cells) and eliminating TICs may offer a new strategy to develop successful anti-cancer therapies. As molecular mechanisms...
5.
Grandinetti K, Jelinic P, DiMauro T, Pellegrino J, Fernandez Rodriguez R, Finnerty P, et al.
Cancer Res
. 2009 Aug;
69(16):6430-7.
PMID: 19654306
Serial passage of primary mammalian cells or strong mitogenic signals induce a permanent exit from the cell cycle called senescence. A characteristic of senescent cells is the heterochromatinization of loci...
6.
Grandinetti K, David G
Cell Cycle
. 2008 May;
7(11):1550-4.
PMID: 18469515
Efficient and accurate cell cycle exit is intimately linked to cellular differentiation, and by inference, to the prevention of tumorigenesis. Perhaps the most important axis of control for this process...
7.
David G, Grandinetti K, Finnerty P, Simpson N, Chu G, DePinho R
Proc Natl Acad Sci U S A
. 2008 Mar;
105(11):4168-72.
PMID: 18332431
The Sin3-histone deacetylase (HDAC) corepressor complex is conserved from yeast to humans. Mammals possess two highly related Sin3 proteins, mSin3A and mSin3B, which serve as scaffolds tethering HDAC enzymatic activity,...