Kathrin Loffler
Overview
Explore the profile of Kathrin Loffler including associated specialties, affiliations and a list of published articles.
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6
Citations
199
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Recent Articles
1.
Rider D, Chivers S, Aretz J, Eisermann M, Loffler K, Hauptmann J, et al.
Toxicol Sci
. 2022 Jun;
189(2):237-249.
PMID: 35737426
SLN360 is a liver-targeted N-acetyl galactosamine (GalNAc)-conjugated small interfering RNA (siRNA) with a promising profile for addressing lipoprotein (a)-related cardiovascular risk. Here, we describe the findings from key preclinical safety...
2.
Rider D, Eisermann M, Loffler K, Aleku M, Swerdlow D, Dames S, et al.
Atherosclerosis
. 2022 Apr;
349:240-247.
PMID: 35400495
Background And Aims: The LPA gene encodes apolipoprotein (a), a key component of Lp(a), a potent risk factor for cardiovascular disease with no specific pharmacotherapy. Here we describe the pharmacological...
3.
Altamura S, Schaeper U, Dames S, Loffler K, Eisermann M, Frauendorf C, et al.
Hemasphere
. 2020 Jan;
3(6):e301.
PMID: 31976476
No abstract available.
4.
Mopert K, Loffler K, Roder N, Kaufmann J, Santel A
Eur J Cell Biol
. 2012 May;
91(9):694-705.
PMID: 22609186
Several pathways are involved in the control of endothelial cell morphology, endothelial permeability and function in order to maintain vascular homeostasis. Here we report that protein kinase N3 (PKN3) appears...
5.
Santel A, Aleku M, Roder N, Mopert K, Durieux B, Janke O, et al.
Clin Cancer Res
. 2010 Nov;
16(22):5469-80.
PMID: 21062934
Purpose: Atu027, a novel RNA interference therapeutic, has been shown to inhibit lymph node metastasis in orthotopic prostate cancer mouse models. The aim of this study is to elucidate the...
6.
Aleku M, Schulz P, Keil O, Santel A, Schaeper U, Dieckhoff B, et al.
Cancer Res
. 2008 Dec;
68(23):9788-98.
PMID: 19047158
We have previously described a small interfering RNA (siRNA) delivery system (AtuPLEX) for RNA interference (RNAi) in the vasculature of mice. Here we report preclinical data for Atu027, a siRNA-lipoplex...