Kathleen Van Craenenbroeck
Overview
Explore the profile of Kathleen Van Craenenbroeck including associated specialties, affiliations and a list of published articles.
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41
Citations
794
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Recent Articles
1.
Janssens J, Crans R, Van Craenenbroeck K, Vandesompele J, Stove C, Van Dam D, et al.
J Neurosci Methods
. 2019 Mar;
320:128-137.
PMID: 30849434
Background: The choice of appropriate reference genes (RGs) for use in reverse transcription quantitative polymerase chain reaction (RT-qPCR) has been thoroughly investigated, since the inclusion of unstable RGs might cause...
2.
Crans R, Janssens J, Daelemans S, Wouters E, Raedt R, Van Dam D, et al.
PLoS One
. 2019 Jan;
14(1):e0210567.
PMID: 30629669
Background: In gene expression studies via RT-qPCR many conclusions are inferred by using reference genes. However, it is generally known that also reference genes could be differentially expressed between various...
3.
Qian M, Wouters E, Dalton J, Risseeuw M, Crans R, Stove C, et al.
J Med Chem
. 2018 Sep;
61(18):8212-8225.
PMID: 30180563
In this study, we designed and synthesized heterobivalent ligands targeting heteromers consisting of the metabotropic glutamate 5 receptor (mGluR5) and the dopamine D receptor (DR). Bivalent ligand 22a with a...
4.
Qian M, Vasudevan L, Huysentruyt J, Risseeuw M, Stove C, Vanderheyden P, et al.
ChemMedChem
. 2018 Feb;
13(9):944-956.
PMID: 29451744
Currently, there is mounting evidence that intermolecular receptor-receptor interactions may result in altered receptor recognition, pharmacology and signaling. Heterobivalent ligands have been proven useful as molecular probes for confirming and...
5.
Storme J, Cannaert A, Van Craenenbroeck K, Stove C
Biochem Pharmacol
. 2018 Jan;
148:298-307.
PMID: 29309765
Besides classical G protein coupling, G protein-coupled receptors (GPCRs) are nowadays well known to show significant signalling via other adaptor proteins, such as β-arrestin2 (βarr2). The elucidation of the molecular...
6.
Skieterska K, Rondou P, Van Craenenbroeck K
Int J Mol Sci
. 2017 Apr;
18(5).
PMID: 28448471
G protein-coupled receptors (GPCRs) comprise the largest family of membrane receptors that control many cellular processes and consequently often serve as drug targets. These receptors undergo a strict regulation by...
7.
Rivera A, Gago B, Suarez-Boomgaard D, Yoshitake T, Roales-Bujan R, Valderrama-Carvajal A, et al.
Addict Biol
. 2016 May;
22(5):1232-1245.
PMID: 27212105
Morphine is one of the most effective drugs used for pain management, but it is also highly addictive. Morphine elicits acute and long-term adaptive changes at cellular and molecular level...
8.
Skieterska K, Shen A, Clarisse D, Rondou P, Borroto-Escuela D, Lintermans B, et al.
Cell Signal
. 2016 May;
28(8):1001-14.
PMID: 27155323
Dopamine receptors are G protein-coupled receptors involved in regulation of cognition, learning, movement and endocrine signaling. The action of G protein-coupled receptors is highly regulated by multifunctional proteins, such as...
9.
Skieterska K, Rondou P, Van Craenenbroeck K
Biochem Soc Trans
. 2016 Apr;
44(2):601-5.
PMID: 27068976
Ubiquitination is a post-translational modification that targets proteins for degradation but can also regulate other cellular processes such as endocytosis, trafficking and DNA repair. We investigate ubiquitination of the dopamine...
10.
Skieterska K, Rondou P, Lintermans B, Van Craenenbroeck K
PLoS One
. 2015 Dec;
10(12):e0145654.
PMID: 26717573
Dopamine D4 Receptor Polymorphism: The dopamine D4 receptor has an important polymorphism in its third intracellular loop that is intensively studied and has been associated with several abnormal conditions, among...