Katharine A Whartenby
Overview
Explore the profile of Katharine A Whartenby including associated specialties, affiliations and a list of published articles.
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37
Citations
1036
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Recent Articles
1.
Gharagozloo M, Smith M, Jin J, Garton T, Taylor M, Chao A, et al.
Acta Neuropathol
. 2021 Sep;
142(5):899-915.
PMID: 34487221
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) characterized by varying degrees of secondary neurodegeneration. Retinal ganglion cells (RGC) are lost in MS in...
2.
Chamling X, Kallman A, Fang W, Berlinicke C, Mertz J, Devkota P, et al.
Nat Commun
. 2021 Jan;
12(1):652.
PMID: 33510160
Injury and loss of oligodendrocytes can cause demyelinating diseases such as multiple sclerosis. To improve our understanding of human oligodendrocyte development, which could facilitate development of remyelination-based treatment strategies, here...
3.
Pantoja I, Smith M, Rajbhandari L, Cheng L, Gao Y, Mahairaki V, et al.
PLoS One
. 2020 Jun;
15(6):e0233980.
PMID: 32511247
Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system (CNS) that results in variable severities of neurodegeneration. The understanding of MS has been limited by...
4.
Glenn J, Pantoja I, Caturegli P, Whartenby K
J Neuroimmunol
. 2019 Nov;
339:577115.
PMID: 31778849
Multiple sclerosis (MS) is an autoimmune disease that remains in need of effective therapies. Plant-derived medicines have appealing properties for the treatment of autoimmune diseases. MYMD-1 is a synthetic plant...
5.
Cardona J, Smith M, Wang J, Kirby L, Schott J, Davidson T, et al.
PLoS One
. 2019 Sep;
14(9):e0221747.
PMID: 31490950
Multiple sclerosis (MS) is characterized by demyelinated lesions in the central nervous system. Destruction of myelin and secondary damage to axons and neurons leads to significant disability, particularly in people...
6.
Fitzgerald K, Kim K, Smith M, Aston S, Fioravante N, Rothman A, et al.
Brain
. 2019 Jul;
142(9):2722-2736.
PMID: 31289819
Multiple sclerosis is a heterogeneous disease with an unpredictable course and a wide range of severity; some individuals rapidly progress to a disabled state whereas others experience only mild symptoms....
7.
Glenn J, Liu C, Whartenby K
J Leukoc Biol
. 2019 Feb;
105(5):829-841.
PMID: 30762897
Myeloid-derived suppressor cells (MDSCs) are a diverse group of cells that are recognized for their remarkable suppressive effects on pro-inflammatory T cells. The pleiotropic nature of these cells, however, has...
8.
Linville R, DeStefano J, Sklar M, Xu Z, Farrell A, Bogorad M, et al.
Biomaterials
. 2018 Nov;
190-191:24-37.
PMID: 30391800
Microvessels of the blood-brain barrier (BBB) regulate transport into the brain. The highly specialized brain microvascular endothelial cells, a major component of the BBB, express tight junctions and efflux transporters...
9.
Glenn J, Xue P, Whartenby K
J Neuroimmunol
. 2017 Dec;
316:7-16.
PMID: 29274729
Pro-inflammatory T cells are critical to the pathogenesis of multiple sclerosis (MS). We investigated the potential for the anti-proliferative, pro-apoptotic drug gemcitabine to affect development of MS-relevant effector T1, T17,...
10.
Glenn J, Smith M, Xue P, Chan-Li Y, Collins S, Calabresi P, et al.
J Exp Med
. 2017 Jan;
214(2):297-307.
PMID: 28057805
The discovery that central nervous system (CNS)-targeted autoreactive T cells required a process of licensing in the lung revealed an unexpected relationship between these organs. The clinical and immunological significance...