Kate M Warde
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Explore the profile of Kate M Warde including associated specialties, affiliations and a list of published articles.
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40
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Recent Articles
1.
Warde K, Smith L, Basham K
J Endocr Soc
. 2023 Aug;
7(9):bvad097.
PMID: 37564884
Aging is characterized by a gradual decline in physiological function. This process affects all organs including the adrenal cortex, which normally functions to produce essential steroid hormones including mineralocorticoids, glucocorticoids,...
2.
Senescence-induced immune remodeling facilitates metastatic adrenal cancer in a sex-dimorphic manner
Warde K, Smith L, Liu L, Stubben C, Lohman B, Willett P, et al.
Nat Aging
. 2023 May;
3(7):846-865.
PMID: 37231196
Aging markedly increases cancer risk, yet our mechanistic understanding of how aging influences cancer initiation is limited. Here we demonstrate that the loss of ZNRF3, an inhibitor of Wnt signaling...
3.
Mullen N, Donlon P, Sebek J, Duffy K, Cappiello G, Feely S, et al.
Endocrinology
. 2023 Mar;
164(5).
PMID: 36932649
Primary aldosteronism is the most common cause of secondary hypertension. The first-line treatment adrenalectomy resects adrenal nodules and adjacent normal tissue, limiting suitability to those who present with unilateral disease....
4.
Warde K, Lim Y, Martinez E, Beuschlein F, OShea P, Hantel C, et al.
Endocrinology
. 2022 Jul;
163(9).
PMID: 35797592
Introduction: Adrenocortical carcinoma (ACC) is a rare aggressive cancer with low overall survival. Adjuvant mitotane improves survival but is limited by poor response rates and resistance. Mitotane's efficacy is attributed...
5.
Warde K, Schoenmakers E, Martinez E, Lim Y, Leonard M, Lawless S, et al.
Endocr Relat Cancer
. 2020 Apr;
27(6):361-373.
PMID: 32276262
Adrenocortical carcinoma (ACC) is a rare aggressive malignancy with a poor outcome largely due to limited treatment options. Here, we propose a novel therapeutic approach through modulating intracellular free cholesterol...