Kasuen Kotagama
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Explore the profile of Kasuen Kotagama including associated specialties, affiliations and a list of published articles.
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9
Citations
82
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Recent Articles
1.
Kotagama K, Grimme A, Braviner L, Yang B, Sakhawala R, Yu G, et al.
Nucleic Acids Res
. 2024 Mar;
52(9):4985-5001.
PMID: 38471816
Many microRNA (miRNA)-guided Argonaute proteins can cleave RNA ('slicing'), even though miRNA-mediated target repression is generally cleavage-independent. Here we use Caenorhabditis elegans to examine the role of catalytic residues of...
2.
Kotagama K, McJunkin K
Semin Cell Dev Biol
. 2023 Apr;
154(Pt A):4-13.
PMID: 37055330
MicroRNAs (miRNAs) were first discovered in C. elegans as essential post-transcriptional regulators of gene expression. Since their initial discovery, miRNAs have been implicated in numerous areas of physiology and disease...
3.
Kotagama K, Grimme A, Braviner L, Yang B, Sakhawala R, Yu G, et al.
bioRxiv
. 2023 Jan;
PMID: 36711716
Many Argonaute proteins can cleave RNA ("slicing") as part of the microRNA-induced silencing complex (miRISC), even though miRNA-mediated target repression is generally independent of target cleavage. Here we use genome...
4.
Kotagama K, Schorr A, Steber H, Mangone M
Genetics
. 2019 May;
212(3):931-951.
PMID: 31073019
MicroRNAs (miRNAs) are known to modulate gene expression, but their activity at the tissue-specific level remains largely uncharacterized. To study their contribution to tissue-specific gene expression, we developed novel tools...
5.
Wolter J, Le H, Linse A, Godlove V, Nguyen T, Kotagama K, et al.
Genome Res
. 2016 Dec;
27(1):53-63.
PMID: 27927717
MicroRNAs (miRNAs) regulate gene output by targeting degenerate elements in mRNAs and have undergone drastic expansions in higher metazoan genomes. The evolutionary advantage of maintaining copies of highly similar miRNAs...
6.
Kotagama K, Babb C, Wolter J, Murphy R, Mangone M
BMC Genomics
. 2015 Dec;
16:1036.
PMID: 26645212
Background: 3'untranslated regions (3'UTRs) are poorly understood portions of eukaryotic mRNAs essential for post-transcriptional gene regulation. Sequence elements in 3'UTRs can be target sites for regulatory molecules such as RNA...
7.
Kotagama K, Chang Y, Mangone M
Drug Dev Res
. 2015 Aug;
76(6):278-85.
PMID: 26284455
Chronic myelogenous leukemia (CML) is a myeloproliferative neoplasm that is frequently characterized by the constitutive expression of the oncogenic protein BCR-ABL tyrosine kinase. Tyrosine kinase inhibitors (TKIs) targeting breakpoint cluster...
8.
Wolter J, Kotagama K, Babb C, Mangone M
J Vis Exp
. 2015 Jun;
(99):e52647.
PMID: 26066857
Luminescent Identification of Functional Elements in 3'UTRs (3'LIFE) allows the rapid identification of targets of specific miRNAs within an array of hundreds of queried 3'UTRs. Target identification is based on...
9.
Wolter J, Kotagama K, Pierre-Bez A, Firago M, Mangone M
Nucleic Acids Res
. 2014 Jul;
42(17):e132.
PMID: 25074381
MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene output at the post-transcriptional level by targeting degenerate elements primarily in 3'untranslated regions (3'UTRs) of mRNAs. Individual miRNAs can regulate networks...