Karthikeyan Radhakrishnan
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Explore the profile of Karthikeyan Radhakrishnan including associated specialties, affiliations and a list of published articles.
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Citations
244
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Recent Articles
11.
Peng J, Alam S, Radhakrishnan K, Mariappan M, Rudolph M, May C, et al.
FEBS J
. 2015 Jun;
282(17):3262-74.
PMID: 26077311
C α-formylglycine (FGly) is the catalytic residue of sulfatases in eukaryotes. It is generated by a unique post-translational modification catalysed by the FGly-generating enzyme (FGE) in the endoplasmic reticulum. FGE...
12.
Baltes J, Larsen J, Radhakrishnan K, Geumann C, Kratzke M, Petersen C, et al.
J Cell Sci
. 2014 Jun;
127(Pt 16):3477-87.
PMID: 24928897
Here, we describe altered sorting of sortilin in adipocytes deficient for the σ1B-containing AP-1 complex, leading to the inhibition of adipogenesis. The AP-1 complex mediates protein sorting between the trans-Golgi...
13.
Radhakrishnan K, Baltes J, Creemers J, Schu P
J Cell Sci
. 2013 Jan;
126(Pt 5):1155-63.
PMID: 23321636
The AP-1 complex recycles between membranes and the cytoplasm and dissociates from membranes during clathrin-coated-vesicle uncoating, but also independently of vesicular transport. The μ1A N-terminal 70 amino acids are involved...
14.
Schlotawa L, Radhakrishnan K, Baumgartner M, Schmid R, Schmidt B, Dierks T, et al.
Eur J Hum Genet
. 2013 Jan;
21(9):1020-3.
PMID: 23321616
Multiple sulfatase deficiency (MSD) is a rare inborn error of metabolism affecting posttranslational activation of sulfatases by the formylglycine generating enzyme (FGE). Due to mutations in the encoding SUMF1 gene,...
15.
Ennemann E, Radhakrishnan K, Mariappan M, Wachs M, Pringle T, Schmidt B, et al.
J Biol Chem
. 2013 Jan;
288(8):5828-39.
PMID: 23288839
Formylglycine-generating enzyme (FGE) post-translationally converts a specific cysteine in newly synthesized sulfatases to formylglycine (FGly). FGly is the key catalytic residue of the sulfatase family, comprising 17 nonredundant enzymes in...
16.
Schlotawa L, Ennemann E, Radhakrishnan K, Schmidt B, Chakrapani A, Christen H, et al.
Eur J Hum Genet
. 2011 Jan;
19(3):253-61.
PMID: 21224894
Multiple Sulfatase Deficiency (MSD) is caused by mutations in the sulfatase-modifying factor 1 gene encoding the formylglycine-generating enzyme (FGE). FGE post translationally activates all newly synthesized sulfatases by generating the...
17.
Dierks T, Schlotawa L, Frese M, Radhakrishnan K, von Figura K, Schmidt B
Biochim Biophys Acta
. 2009 Jan;
1793(4):710-25.
PMID: 19124046
Multiple sulfatase deficiency (MSD), mucolipidosis (ML) II/III and Niemann-Pick type C1 (NPC1) disease are rare but fatal lysosomal storage disorders caused by the genetic defect of non-lysosomal proteins. The NPC1...
18.
Mariappan M, Gande S, Radhakrishnan K, Schmidt B, Dierks T, von Figura K
J Biol Chem
. 2008 Feb;
283(17):11556-64.
PMID: 18305113
Formylglycine-generating enzyme (FGE) catalyzes the oxidation of a specific cysteine residue in nascent sulfatase polypeptides to formylglycine (FGly). This FGly is part of the active site of all sulfatases and...
19.
Mariappan M, Radhakrishnan K, Dierks T, Schmidt B, von Figura K
J Biol Chem
. 2008 Jan;
283(10):6375-83.
PMID: 18178549
Inside the endoplasmic reticulum (ER) formylglycine-generating enzyme (FGE) catalyzes in newly synthesized sulfatases the post-translational oxidation of a specific cysteine. Thereby formylglycine is generated, which is essential for sulfatase activity....
20.
Medigeshi G, Krikunova M, Radhakrishnan K, Wenzel D, Klingauf J, Schu P
Traffic
. 2007 Nov;
9(1):121-32.
PMID: 17988225
The adaptor protein complex AP-1 mediates vesicular protein sorting between the trans Golgi network and endosomes. AP-1 recycles between membranes and the cytoplasm together with clathrin during transport vesicle formation...