Karthik B Jeganathan
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Explore the profile of Karthik B Jeganathan including associated specialties, affiliations and a list of published articles.
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36
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3744
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Recent Articles
1.
Carver C, Rodriguez S, Atkinson E, Dosch A, Asmussen N, Gomez P, et al.
Nat Aging
. 2024 Dec;
5(2):291-305.
PMID: 39658621
Cellular senescence is an aging mechanism characterized by cell cycle arrest and a senescence-associated secretory phenotype (SASP). Preclinical studies demonstrate that senolytic drugs, which target survival pathways in senescent cells,...
2.
Schultz D, Davies B, Payne J, Martin C, Minard A, Childs B, et al.
J Cell Sci
. 2024 Aug;
137(18).
PMID: 39155850
His domain protein tyrosine phosphatase (HD-PTP; also known as PTPN23) facilitates function of the endosomal sorting complexes required for transport (ESCRTs) during multivesicular body (MVB) formation. To uncover its role...
3.
van Ree J, Jeganathan K, Fierro Velasco R, Zhang C, Can I, Hamada M, et al.
Nat Commun
. 2023 May;
14(1):2983.
PMID: 37225693
PTEN is a multifaceted tumor suppressor that is highly sensitive to alterations in expression or function. The PTEN C-tail domain, which is rich in phosphorylation sites, has been implicated in...
4.
Sturmlechner I, Sine C, Jeganathan K, Zhang C, Fierro Velasco R, Baker D, et al.
Nat Commun
. 2022 Jun;
13(1):3722.
PMID: 35764649
Super-enhancers regulate genes with important functions in processes that are cell type-specific or define cell identity. Mouse embryonic fibroblasts establish 40 senescence-associated super-enhancers regardless of how they become senescent, with...
5.
Limzerwala J, Jeganathan K, Kloeber J, Davies B, Zhang C, Sturmlechner I, et al.
Nat Cancer
. 2021 Nov;
1(10):1010-1024.
PMID: 34841254
FoxM1 activates genes that regulate S-G2-M cell-cycle progression and, when overexpressed, is associated with poor clinical outcome in multiple cancers. Here we identify FoxM1 as a tumor suppressor in mice...
6.
Sturmlechner I, Zhang C, Sine C, van Deursen E, Jeganathan K, Hamada N, et al.
Science
. 2021 Oct;
374(6567):eabb3420.
PMID: 34709885
Immune cells identify and destroy damaged cells to prevent them from causing cancer or other pathologies by mechanisms that remain poorly understood. Here, we report that the cell-cycle inhibitor p21...
7.
Sieben C, Jeganathan K, Nelson G, Sturmlechner I, Zhang C, van Deursen W, et al.
J Clin Invest
. 2020 Nov;
130(11):6188.
PMID: 33136097
No abstract available.
8.
Sieben C, Jeganathan K, Nelson G, Sturmlechner I, Zhang C, van Deursen W, et al.
J Clin Invest
. 2019 Nov;
130(1):171-188.
PMID: 31738183
Mosaic-variegated aneuploidy (MVA) syndrome is a rare childhood disorder characterized by biallelic BUBR1, CEP57, or TRIP13 aberrations; increased chromosome missegregation; and a broad spectrum of clinical features, including various cancers,...
9.
Aziz K, Limzerwala J, Sturmlechner I, Hurley E, Zhang C, Jeganathan K, et al.
Gastroenterology
. 2019 Mar;
157(1):210-226.e12.
PMID: 30878468
Background & Aims: The CCNE1 locus, which encodes cyclin E1, is amplified in many types of cancer cells and is activated in hepatocellular carcinomas (HCCs) from patients infected with hepatitis...
10.
Aziz K, Sieben C, Jeganathan K, Hamada M, Davies B, Fierro Velasco R, et al.
J Clin Invest
. 2018 Jul;
128(8):3517-3534.
PMID: 30035751
A homozygous truncating frameshift mutation in CEP57 (CEP57T/T) has been identified in a subset of mosaic-variegated aneuploidy (MVA) patients; however, the physiological roles of the centrosome-associated protein CEP57 that contribute...