Karl Olafsson
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Explore the profile of Karl Olafsson including associated specialties, affiliations and a list of published articles.
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10
Citations
665
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Recent Articles
1.
Olafsdottir T, Stacey S, Sveinbjornsson G, Thorleifsson G, Norland K, Sigurgeirsson B, et al.
Cancer Res
. 2021 Feb;
81(8):1954-1964.
PMID: 33602785
The success of genome-wide association studies (GWAS) in identifying common, low-penetrance variant-cancer associations for the past decade is undisputed. However, discovering additional high-penetrance cancer mutations in unknown cancer predisposing genes...
2.
Olafsdottir T, Thorleifsson G, Sulem P, Stefansson O, Medek H, Olafsson K, et al.
Commun Biol
. 2020 Mar;
3(1):129.
PMID: 32184442
Pelvic organ prolapse (POP) is a downward descent of one or more of the pelvic organs, resulting in a protrusion of the vaginal wall and/or uterus. We performed a genome-wide...
3.
Olafsson S, Alexandersson K, Gizurarson J, Hauksdottir K, Gunnarsson O, Olafsson K, et al.
Cancer Epidemiol Biomarkers Prev
. 2019 Nov;
29(1):225-235.
PMID: 31666285
Background: Alpha-fetoprotein (AFP), cancer antigens 15.3, 19.9, and 125, carcinoembryonic antigen, and alkaline phosphatase (ALP) are widely measured in attempts to detect cancer and to monitor treatment response. However, due...
4.
Rafnar T, Gunnarsson B, Stefansson O, Sulem P, Ingason A, Frigge M, et al.
Nat Commun
. 2018 Sep;
9(1):3636.
PMID: 30194396
Uterine leiomyomas are common benign tumors of the myometrium. We performed a meta-analysis of two genome-wide association studies of leiomyoma in European women (16,595 cases and 523,330 controls), uncovering 21...
5.
Rafnar T, Gudbjartsson D, Sulem P, Jonasdottir A, Sigurdsson A, Jonasdottir A, et al.
Nat Genet
. 2011 Oct;
43(11):1104-7.
PMID: 21964575
Ovarian cancer causes more deaths than any other gynecologic malignancy in developed countries. Sixteen million sequence variants, identified through whole-genome sequencing of 457 Icelanders, were imputed to 41,675 Icelanders genotyped...
6.
Agustsson A, Olafsson K, Thorisdottir A
Acta Obstet Gynecol Scand
. 2009 Jul;
88(10):1171-3.
PMID: 19639457
Salmonella osteomyelitis is rare in the immunocompetent host, even though Salmonella is not an infrequent public health problem. Invasive salmonellosis has in general a poor outcome in pregnancy with regard...
7.
Rafnar T, Sulem P, Stacey S, Geller F, Gudmundsson J, Sigurdsson A, et al.
Nat Genet
. 2009 Jan;
41(2):221-7.
PMID: 19151717
The common sequence variants that have recently been associated with cancer risk are particular to a single cancer type or at most two. Following up on our genome-wide scan of...
8.
Gudmundsson K, Thorsteinsson L, Sigurjonsson O, Keller J, Olafsson K, Egeland T, et al.
Stem Cells
. 2007 Feb;
25(6):1498-506.
PMID: 17322106
Inducible hematopoietic stem/progenitor cell lines represent a model for studying genes involved in self-renewal and differentiation. Here, gene expression was studied in the inducible human CD34+ acute myelogenous leukemia cell...
9.
Rafnar T, Benediktsdottir K, Eldon B, Gestsson T, Saemundsson H, Olafsson K, et al.
Eur J Cancer
. 2004 Dec;
40(18):2788-93.
PMID: 15571962
A single founder mutation in each of the BRCA genes has been identified in Iceland. The frequency of the BRCA1 G5193A and BRCA2 999del5 mutations in all ovarian cancer patients...
10.
Mikaelsdottir E, Benediktsdottir K, Olafsdottir K, Arnadottir T, Ragnarsson G, Olafsson K, et al.
Gynecol Oncol
. 2003 Apr;
89(1):22-30.
PMID: 12694650
Objective: Cervical cancer is a disease caused in part by an infection with an oncogenic subtype of human papillomavirus (HPV). In this study we analysed all cervical cancer samples diagnosed...