Karl J Smalley
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Explore the profile of Karl J Smalley including associated specialties, affiliations and a list of published articles.
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11
Citations
203
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0
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Recent Articles
1.
Fong L, Huebner K, Jing R, Smalley K, Brydges C, Fiehn O, et al.
Proc Natl Acad Sci U S A
. 2023 May;
120(20):e2220334120.
PMID: 37155893
Esophageal squamous cell carcinoma (ESCC) is a deadly disease with few prevention or treatment options. ESCC development in humans and rodents is associated with Zn deficiency (ZD), inflammation, and overexpression...
2.
Fong L, Taccioli C, Palamarchuk A, Tagliazucchi G, Jing R, Smalley K, et al.
Proc Natl Acad Sci U S A
. 2020 Mar;
117(11):6075-6085.
PMID: 32123074
MicroRNA-31 (miR-31) is overexpressed in esophageal squamous cell carcinoma (ESCC), a deadly disease associated with dietary Zn deficiency and inflammation. In a Zn deficiency-promoted rat ESCC model with miR-31 up-regulation,...
3.
Fong L, Jing R, Smalley K, Wang Z, Taccioli C, Fan S, et al.
Proc Natl Acad Sci U S A
. 2018 Nov;
115(47):E11091-E11100.
PMID: 30397150
Prostate cancer is a leading cause of cancer death in men over 50 years of age, and there is a characteristic marked decrease in Zn content in the malignant prostate...
4.
Fong L, Jing R, Smalley K, Taccioli C, Fahrmann J, Barupal D, et al.
Oncotarget
. 2017 Nov;
8(47):81910-81925.
PMID: 29137232
Esophageal squamous cell carcinoma (ESCC) in humans is a deadly disease associated with dietary zinc (Zn)-deficiency. In the rat esophagus, Zn-deficiency induces cell proliferation, alters mRNA and microRNA gene expression,...
5.
Fong L, Taccioli C, Jing R, Smalley K, Alder H, Jiang Y, et al.
Oncotarget
. 2016 Feb;
7(10):10723-38.
PMID: 26918602
Zinc deficiency (ZD) increases the risk of esophageal squamous cell carcinoma (ESCC), and marginal ZD is prevalent in humans. In rats, marked-ZD (3 mg Zn/kg diet) induces a proliferative esophagus...
6.
Taccioli C, Garofalo M, Chen H, Jiang Y, Tagliazucchi G, Di Leva G, et al.
J Natl Cancer Inst
. 2015 Aug;
107(11).
PMID: 26286729
Background: Overexpression of microRNA-31 (miR-31) is implicated in the pathogenesis of esophageal squamous cell carcinoma (ESCC), a deadly disease associated with dietary zinc deficiency. Using a rat model that recapitulates...
7.
Alder H, Taccioli C, Chen H, Jiang Y, Smalley K, Fadda P, et al.
Carcinogenesis
. 2012 Jun;
33(9):1736-44.
PMID: 22689922
Zinc deficiency (ZD) increases the risk of esophageal squamous cell carcinoma (ESCC). In a rat model, chronic ZD induces an inflammatory gene signature that fuels ESCC development. microRNAs regulate gene...
8.
Fong L, Jiang Y, Rawahneh M, Smalley K, Croce C, Farber J, et al.
Carcinogenesis
. 2011 Jan;
32(4):554-60.
PMID: 21245412
Dietary zinc (Zn) deficiency is implicated in the pathogenesis of human oral-esophageal cancers. In rats, Zn deficiency causes increased cell proliferation and cyclooxygenase-2 (COX-2) overexpression and enhances oral carcinogenesis by...
9.
Wan S, Taccioli C, Jiang Y, Chen H, Smalley K, Huang K, et al.
Int J Cancer
. 2010 Sep;
129(2):331-45.
PMID: 20857495
Zinc (Zn)-deficiency (ZD) is implicated in the pathogenesis of human oral-esophageal cancers. Previously, we showed that in ZD mice genetic deletion of cyclooxygenase-2 (Cox-2) enhances N-nitrosomethylbenzylamine-induced forestomach carcinogenesis. By contrast,...
10.
London J, Smalley K, Conner K, Smith J
Clin Trials
. 2009 Sep;
6(5):446-54.
PMID: 19737847
Background: The reporting of serious adverse events is a requirement when conducting a clinical trial involving human subjects, necessary for the protection of the participants. The reporting process is a...