Karl-Ferdinand Lechtreck
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Explore the profile of Karl-Ferdinand Lechtreck including associated specialties, affiliations and a list of published articles.
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17
Citations
1016
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Recent Articles
1.
Wingfield J, Lechtreck K, Lorentzen E
Essays Biochem
. 2018 Oct;
62(6):753-763.
PMID: 30287585
Bardet-Biedl syndrome (BBS) is a rare inherited disease caused by defects in the BBSome, an octameric complex of BBS proteins. The BBSome is conserved in most organisms with cilia, which...
2.
Wingfield J, Lechtreck K
Cells
. 2018 Jul;
7(7).
PMID: 30018231
During ciliogenesis, centrioles convert to membrane-docked basal bodies, which initiate the formation of cilia/flagella and template the nine doublet microtubules of the flagellar axoneme. The discovery that many human diseases...
3.
Getting tubulin to the tip of the cilium: one IFT train, many different tubulin cargo-binding sites?
Bhogaraju S, Weber K, Engel B, Lechtreck K, Lorentzen E
Bioessays
. 2014 Mar;
36(5):463-7.
PMID: 24616010
Cilia are microtubule-based hair-like structures that project from the surfaces of eukaryotic cells. Cilium formation relies on intraflagellar transport (IFT) to move ciliary proteins such as tubulin from the site...
4.
Lechtreck K, Gould T, Witman G
Cilia
. 2013 Nov;
2(1):15.
PMID: 24283352
Background: Most motile cilia and flagella have nine outer doublet and two central pair (CP) microtubules. Outer doublet microtubules are continuous with the triplet microtubules of the basal body, are...
5.
Craige B, Tsao C, Diener D, Hou Y, Lechtreck K, Rosenbaum J, et al.
J Cell Biol
. 2010 Sep;
190(5):927-40.
PMID: 20819941
Mutations in human CEP290 cause cilia-related disorders that range in severity from isolated blindness to perinatal lethality. Here, we describe a Chlamydomonas reinhardtii mutant in which most of the CEP290...
6.
Engel B, Lechtreck K, Sakai T, Ikebe M, Witman G, Marshall W
Methods Cell Biol
. 2010 Apr;
93:157-77.
PMID: 20409817
The eukaryotic flagellum is host to a variety of dynamic behaviors, including flagellar beating, the motility of glycoproteins in the flagellar membrane, and intraflagellar transport (IFT), the bidirectional traffic of...
7.
Lechtreck K, Sanderson M, Witman G
Methods Cell Biol
. 2010 Apr;
91:255-64.
PMID: 20409790
The development and health of mammals requires proper ciliary motility. Ciliated epithelia are found in the airways, the uterus and Fallopian tubes, the efferent ducts of the testes, and the...
8.
Lechtreck K, Johnson E, Sakai T, Cochran D, Ballif B, Rush J, et al.
J Cell Biol
. 2009 Dec;
187(7):1117-32.
PMID: 20038682
In humans, seven evolutionarily conserved genes that cause the cilia-related disorder Bardet-Biedl syndrome (BBS) encode proteins that form a complex termed the BBSome. The function of the BBSome in the...
9.
Lechtreck K, Luro S, Awata J, Witman G
Cell Motil Cytoskeleton
. 2009 Apr;
66(8):469-82.
PMID: 19382199
Proteomic analysis of flagella from the green alga Chlamydomonas reinhardtii has identified over 600 putative flagellar proteins. The genes encoding nine of these not previously characterized plus the previously described...
10.
Lechtreck K, Delmotte P, Robinson M, Sanderson M, Witman G
J Cell Biol
. 2008 Feb;
180(3):633-43.
PMID: 18250199
Chlamydomonas reinhardtii hydin is a central pair protein required for flagellar motility, and mice with Hydin defects develop lethal hydrocephalus. To determine if defects in Hydin cause hydrocephalus through a...