Karin Fritz-Wolf
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Explore the profile of Karin Fritz-Wolf including associated specialties, affiliations and a list of published articles.
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462
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Recent Articles
11.
Brandstaedter C, Fritz-Wolf K, Weder S, Fischer M, Hecker B, Rahlfs S, et al.
FEBS J
. 2017 Dec;
285(3):542-558.
PMID: 29222842
Database: EC numbers: 1.8.1.9; 1.8.1.B1.
12.
Bathke J, Fritz-Wolf K, Brandstadter C, Burkhardt A, Jortzik E, Rahlfs S, et al.
J Mol Biol
. 2016 Dec;
428(24 Pt B):4946-4961.
PMID: 27984041
Nicotinic acid mononucleotide adenylyltransferase (NaMNAT) is an indispensable enzyme for the synthesis of NAD and NAD phosphate. It catalyzes the adenylylation of nicotinic acid mononucleotide (NaMN) to yield nicotinic acid...
13.
Pretzel J, Gehr M, Eisenkolb M, Wang L, Fritz-Wolf K, Rahlfs S, et al.
J Biochem
. 2016 Jul;
160(6):355-367.
PMID: 27466371
As a methyl group donor for biochemical reactions, S-adenosylmethionine plays a central metabolic role in most organisms. Depletion of S-adenosylmethionine has downstream effects on polyamine metabolism and methylation reactions, and...
14.
Wang L, Delahunty C, Fritz-Wolf K, Rahlfs S, Prieto J, Yates J, et al.
Sci Rep
. 2015 Dec;
5:17818.
PMID: 26639022
In eukaryotic cells, the ubiquitin-proteasome system as a key regulator of protein quality control is an excellent drug target. We therefore aimed to analyze the 26S proteasome complex in the...
15.
Mailu B, Li L, Arthur J, Nelson T, Ramasamy G, Fritz-Wolf K, et al.
J Biol Chem
. 2015 Aug;
290(49):29629-41.
PMID: 26318454
The malaria parasite Plasmodium falciparum apicoplast indirect aminoacylation pathway utilizes a non-discriminating glutamyl-tRNA synthetase to synthesize Glu-tRNA(Gln) and a glutaminyl-tRNA amidotransferase to convert Glu-tRNA(Gln) to Gln-tRNA(Gln). Here, we show that...
16.
Fritz-Wolf K, Jortzik E, Stumpf M, Preuss J, Iozef R, Rahlfs S, et al.
J Mol Biol
. 2013 Jul;
425(18):3446-60.
PMID: 23845423
Over the last decades, malaria parasites have been rapidly developing resistance against antimalarial drugs, which underlines the need for novel drug targets. Thioredoxin reductase (TrxR) is crucially involved in redox...
17.
Saul V, de la Vega L, Milanovic M, Kruger M, Braun T, Fritz-Wolf K, et al.
J Mol Cell Biol
. 2012 Sep;
5(1):27-38.
PMID: 23000554
The multitude of mechanisms regulating the activity of protein kinases includes phosphorylation of amino acids contained in the activation loop. Here we show that the serine/threonine kinase HIPK2 (homeodomain-interacting protein...
18.
Zocher K, Fritz-Wolf K, Kehr S, Fischer M, Rahlfs S, Becker K
Mol Biochem Parasitol
. 2012 Feb;
183(1):52-62.
PMID: 22342964
Glutamate dehydrogenases (GDHs) play key roles in cellular redox, amino acid, and energy metabolism, thus representing potential targets for pharmacological interventions. Here we studied the functional network provided by the...
19.
Fritz-Wolf K, Kehr S, Stumpf M, Rahlfs S, Becker K
Nat Commun
. 2011 Jul;
2:383.
PMID: 21750537
Thioredoxin reductase 1 (TrxR1) is a homodimeric flavoprotein crucially involved in the regulation of cellular redox homeostasis, growth, and differentiation. Its importance in various diseases makes TrxR1 a highly interesting...
20.
Sibbing D, Pfeufer A, Perisic T, Mannes A, Fritz-Wolf K, Unwin S, et al.
Eur Heart J
. 2011 Jan;
32(9):1121-33.
PMID: 21247928
Aims: Cardiac energy requirement is met to a large extent by oxidative phosphorylation in mitochondria that are highly abundant in cardiac myocytes. Human mitochondrial thioredoxin reductase (TXNRD2) is a selenocysteine-containing...