Karin A van Schie
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Explore the profile of Karin A van Schie including associated specialties, affiliations and a list of published articles.
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14
Citations
249
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Recent Articles
1.
Yaykasli K, van Schie K, Toes R, Wuhrer M, Koeleman C, Bila G, et al.
Int J Mol Sci
. 2024 Jun;
25(12).
PMID: 38928183
Sepsis is a life-threatening condition with a rising disease burden worldwide. It is a multifactorial disease and is defined as a dysregulated host response to infection. Neutrophils have been shown...
2.
Bacon A, Cartagena Garcia C, van Schie K, Toes R, Busnel J
Autoimmunity
. 2024 Apr;
57(1):2341629.
PMID: 38616577
Most investigations on the immune cell-activating potency of IgA used purified total IgA and/or specific isolated cell populations. As IgA2 has been reported to be more pro-inflammatory than IgA1, we...
3.
Stork E, van Rijswijck D, van Schie K, Hoek M, Kissel T, Scherer H, et al.
Nat Commun
. 2024 Apr;
15(1):3114.
PMID: 38600082
The presence of autoantibodies is a defining feature of many autoimmune diseases. The number of unique autoantibody clones is conceivably limited by immune tolerance mechanisms, but unknown due to limitations...
4.
Volkov M, Brinkhaus M, van Schie K, Bondt A, Kissel T, van der Kooi E, et al.
J Immunol
. 2022 Dec;
210(2):158-167.
PMID: 36480251
Abs can be glycosylated in both their Fc and Fab regions with marked effects on Ab function and binding. High levels of IgG Fab glycosylation are associated with malignant and...
5.
Volkov M, Coppola M, Huizinga R, Eftimov F, Huizinga T, van der Kooi A, et al.
J Allergy Clin Immunol
. 2022 Nov;
150(5):999-1010.
PMID: 36336400
The presence of autoreactive antibodies is a hallmark of many autoimmune diseases. The effector functions of (auto)antibodies are determined by their constant domain, which defines the antibody isotype and subclass....
6.
Sonigra A, Nel H, Wehr P, Ramnoruth N, Patel S, van Schie K, et al.
JCI Insight
. 2022 Oct;
7(20).
PMID: 36278483
BACKGROUNDAntigen-specific regulation of autoimmune disease is a major goal. In seropositive rheumatoid arthritis (RA), T cell help to autoreactive B cells matures the citrullinated (Cit) antigen-specific immune response, generating RA-specific...
7.
Kissel T, Ge C, Hafkenscheid L, Kwekkeboom J, Slot L, Cavallari M, et al.
Sci Adv
. 2022 Feb;
8(6):eabm1759.
PMID: 35138894
The hallmark autoantibodies in rheumatoid arthritis are characterized by variable domain glycans (VDGs). Their abundant occurrence results from the selective introduction of N-linked glycosylation sites during somatic hypermutation, and their...
8.
van Schie K, Kruithof S, Ooijevaar-De Heer P, Derksen N, van de Bovenkamp F, Saris A, et al.
Ann Rheum Dis
. 2018 Jun;
77(10):1471-1479.
PMID: 29945923
Objectives: Therapeutic antibodies can provoke an antidrug antibody (ADA) response, which can form soluble immune complexes with the drug in potentially high amounts. Nevertheless, ADA-associated adverse events are usually rare,...
9.
Bloemendaal F, Koelink P, van Schie K, Rispens T, Peters C, Buskens C, et al.
J Crohns Colitis
. 2018 Jun;
12(9):1122-1130.
PMID: 29860435
Background And Aims: We have recently shown that the mode of action of IgG1 anti-tumour necrosis factor [TNF] antibodies in inflammatory bowel disease [IBD] requires Fcγ-receptor [FcγR] engagement on macrophages....
10.
van de Bovenkamp F, Derksen N, Ooijevaar-De Heer P, van Schie K, Kruithof S, Berkowska M, et al.
Proc Natl Acad Sci U S A
. 2018 Feb;
115(8):1901-1906.
PMID: 29432186
A hallmark of B-cell immunity is the generation of a diverse repertoire of antibodies from a limited set of germline V(D)J genes. This repertoire is usually defined in terms of...