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Karen S L Lam

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Articles 232
Citations 10514
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Recent Articles
1.
Su X, Cheung C, Zhong J, Ru Y, Fong C, Lee C, et al.
J Adv Res . 2023 Nov; 64:131-142. PMID: 38030128
Introduction: Type 2 diabetes (T2D) is a heterogeneous metabolic disease with large variations in the relative contributions of insulin resistance and β-cell dysfunction across different glucose tolerance subgroups and ethnicities....
2.
Lam S, Lee C, Fong C, Wong Y, Shiu S, Mak L, et al.
J Clin Endocrinol Metab . 2023 Nov; 109(3):e1048-e1054. PMID: 37933700
Background And Aims: Tsukushi (TSK) is a recently identified hepatokine, and we aimed to investigate the association between systemic TSK and the severity of nonalcoholic fatty liver disease (NAFLD) in...
3.
Jia X, Song E, Liu Y, Chen J, Wan P, Hu Y, et al.
Cell Rep Med . 2023 Nov; 4(11):101257. PMID: 37918406
The definitive diagnosis of non-alcoholic steatohepatitis (NASH) currently relies on invasive and labor-intensive liver biopsy. Here, we identified soluble CUB domain-containing protein 1 (sCDCP1) as a top-ranked non-invasive biomarker for...
4.
Diaz-Canestro C, Chen J, Liu Y, Han H, Wang Y, Honore E, et al.
Cell Rep Med . 2023 Feb; 4(2):100944. PMID: 36787735
The molecular transducers conferring the benefits of chronic exercise in diabetes prevention remain to be comprehensively investigated. Herein, serum proteomic profiling of 688 inflammatory and metabolic biomarkers in 36 medication-naive...
5.
Chen K, Cheong L, Gao Y, Zhang Y, Feng T, Wang Q, et al.
Nat Commun . 2022 Dec; 13(1):7838. PMID: 36539421
Thyroid hormone (TH) is a thermogenic activator with anti-obesity potential. However, systemic TH administration has no obvious clinical benefits on weight reduction. Herein we selectively delivered triiodothyronine (T3) to adipose...
6.
Geng L, Wong C, Liao B, Lin Y, Han H, Lam K, et al.
Front Endocrinol (Lausanne) . 2022 Nov; 13:1029297. PMID: 36387920
Differential diagnosis of hypoglycaemia can at times be challenging for patients who appear to be well. Here we identify the case of a 66-year-old Chinese man presenting with recurrent episodes...
7.
Zhong J, Cheung C, Su X, Lee C, Ru Y, Fong C, et al.
Cardiovasc Diabetol . 2022 Nov; 21(1):234. PMID: 36335348
Background: Bioactive lipids play an important role in insulin secretion and sensitivity, contributing to the pathophysiology of type 2 diabetes (T2D). This study aimed to identify novel lipid species associated...
8.
Lee C, Lui D, Lam K
J Diabetes Investig . 2022 Feb; 13(5):762-764. PMID: 35119217
No abstract available.
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Yang R, Hu Y, Lee C, Liu Y, Diaz-Canestro C, Fong C, et al.
Eur J Endocrinol . 2021 Nov; 186(2):151-161. PMID: 34757919
Objective: Peptidase M20 domain containing 1 (PM20D1), a secreted enzyme catalysing condensation of fatty acids and amino acids into the bioactive lipids N-acyl amino acids (NAAA), induces uncoupling protein 1...