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Karen R Jacobson

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Recent Articles
11.
Kulkarni S, Weber S, Buys C, Lambrechts T, Myers B, Drainoni M, et al.
Res Sq . 2023 Oct; PMID: 37841852
Background: Unhealthy alcohol use is widespread in South Africa and has been linked to tuberculosis (TB) disease and poor treatment outcomes. This study used qualitative methods to explore the relationship...
12.
Esmail H, Coussens A, Thienemann F, Sossen B, Mukasa S, Warwick J, et al.
medRxiv . 2023 Jul; PMID: 37461515
Background: The evolution of tuberculosis (TB) disease during the clinical latency period remains incompletely understood. Methods: 250 HIV-uninfected, adult household contacts of rifampicin-resistant TB with a negative symptom screen underwent...
13.
Hahn J, Ngabirano C, Fatch R, Emenyonu N, Cheng D, Adong J, et al.
AIDS . 2023 Jun; 37(10):1535-1543. PMID: 37260251
Objective: Isoniazid (INH) preventive therapy is recommended to prevent tuberculosis (TB) disease for persons with HIV (PWH), except for those with regular and heavy alcohol consumption, due to hepatotoxicity concerns....
14.
Adeoye B, Nakiyingi L, Moreau Y, Nankya E, Olson A, Zhang M, et al.
iScience . 2023 May; 26(5):106631. PMID: 37168567
(Mtb) is the most common infection among people with HIV (PWH). Mtb disease-associated inflammation could affect HIV-directed immune responses in PWH. We show that HIV antibodies are broader and more...
15.
Sinha P, Jacobson K, Horsburgh Jr C, Acuna-Villaorduna C
Open Forum Infect Dis . 2023 May; 10(4):ofad177. PMID: 37125228
Multidrug-resistant tuberculosis (MDR-TB) has historically required longer treatment regimens that were associated with higher unfavorable outcomes and side effects rates compared with drug susceptible TB (DS-TB). During the last decade,...
16.
Fofana A, Moultrie H, Scott L, Jacobson K, Shapiro A, Dor G, et al.
Sci Rep . 2023 Feb; 13(1):2674. PMID: 36792792
Human migration facilitates the spread of infectious disease. However, little is known about the contribution of migration to the spread of tuberculosis in South Africa. We analyzed longitudinal data on...
17.
Malatesta S, Weir I, Weber S, Bouton T, Carney T, Theron D, et al.
BMC Med Res Methodol . 2022 Nov; 22(1):297. PMID: 36402979
Background: The occurrence and timing of mycobacterial culture conversion is used as a proxy for tuberculosis treatment response. When researchers serially sample sputum during tuberculosis studies, contamination or missed visits...
18.
Forman L, Lodi S, Fatch R, Emenyonu N, Adong J, Ngabirano C, et al.
Open Forum Infect Dis . 2022 Nov; 9(10):ofac516. PMID: 36320196
Background: Isoniazid (INH) preventative therapy is recommended for people with HIV (PWH) in resource-constrained settings. Valid measures are needed to assess adherence. We aimed to examine agreement between measures overall...
19.
Muyindike W, Fatch R, Cheng D, Emenyonu N, Forman L, Ngabirano C, et al.
J Acquir Immune Defic Syndr . 2022 Aug; 91(5):460-468. PMID: 36044285
Background: Unhealthy alcohol use is associated with increased progression to tuberculosis (TB) disease, but its effect on adherence to isoniazid (INH) preventive therapy is not known. Methods: This was a...
20.
Turcinovic J, Schaeffer B, Taylor B, Bouton T, Odom-Mabey A, Weber S, et al.
J Infect Dis . 2022 Aug; 226(10):1704-1711. PMID: 35993116
Background: Throughout the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, healthcare workers (HCWs) have faced risk of infection from within the workplace via patients and staff as well as...