Karen Mungall
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Explore the profile of Karen Mungall including associated specialties, affiliations and a list of published articles.
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38
Citations
8417
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Recent Articles
1.
Titmuss E, Yu I, Pleasance E, Williamson L, Mungall K, Mungall A, et al.
Curr Oncol
. 2024 Apr;
31(4):1865-1875.
PMID: 38668043
Immune checkpoint inhibitors (ICIs) are increasingly used in the treatment of many tumor types, and durable responses can be observed in select populations. However, patients may exhibit significant immune-related adverse...
2.
Tsang E, Csizmok V, Williamson L, Pleasance E, Topham J, Karasinska J, et al.
NPJ Precis Oncol
. 2023 Mar;
7(1):31.
PMID: 36964191
There is emerging evidence about the predictive role of homologous recombination deficiency (HRD), but this is less defined in gastrointestinal (GI) and thoracic malignancies. We reviewed whole genome (WGS) and...
3.
Thomas N, Dreval K, Gerhard D, Hilton L, Abramson J, Ambinder R, et al.
Blood
. 2022 Oct;
141(8):904-916.
PMID: 36201743
Burkitt lymphoma (BL) accounts for most pediatric non-Hodgkin lymphomas, being less common but significantly more lethal when diagnosed in adults. Much of the knowledge of the genetics of BL thus...
4.
Tessier-Cloutier B, Grewal J, Jones M, Pleasance E, Shen Y, Cai E, et al.
J Pathol Clin Res
. 2022 Mar;
8(4):395-407.
PMID: 35257510
In this study, we evaluate the impact of whole genome and transcriptome analysis (WGTA) on predictive molecular profiling and histologic diagnosis in a cohort of advanced malignancies. WGTA was used...
5.
Feng X, Pleasance E, Zhao E, Ng T, Grewal J, Mohammad N, et al.
JCO Precis Oncol
. 2022 Feb;
3:1-25.
PMID: 35100702
Purpose: This study investigated therapeutic potential of integrated genome and transcriptome profiling of metastatic sarcoma, a rare but extremely heterogeneous group of aggressive mesenchymal malignancies with few systemic therapeutic options....
6.
Britton H, Levine A, Shen Y, Mungall K, Serrano J, Snuderl M, et al.
Clin Case Rep
. 2021 Mar;
9(3):1472-1477.
PMID: 33768871
This is the first report of a NACC2-NTRK2 fusion in a histological glioblastoma. Oncogenomic analysis revealed this actionable fusion oncogene in a pediatric cerebellar glioblastoma, which would not have been...
7.
Tsang E, Grisdale C, Pleasance E, Topham J, Mungall K, Reisle C, et al.
Clin Cancer Res
. 2020 Nov;
27(2):522-531.
PMID: 33148671
Purpose: Gene fusions are important oncogenic drivers and many are actionable. Whole-genome and transcriptome (WGS and RNA-seq, respectively) sequencing can discover novel clinically relevant fusions. Experimental Design: Using WGS and...
8.
Haile S, Corbett R, Bilobram S, Mungall K, Grande B, Kirk H, et al.
PLoS One
. 2019 Nov;
14(10):e0224578.
PMID: 31671154
Next generation RNA-sequencing (RNA-seq) is a flexible approach that can be applied to a range of applications including global quantification of transcript expression, the characterization of RNA structure such as...
9.
Wong D, Shen Y, Levine A, Pleasance E, Jones M, Mungall K, et al.
Cold Spring Harb Mol Case Stud
. 2019 Aug;
5(4).
PMID: 31371350
Effective management of brain and spine tumors relies on a multidisciplinary approach encompassing surgery, radiation, and systemic therapy. In the era of personalized oncology, the latter is complemented by various...
10.
Tsang E, Shen Y, Chooback N, Ho C, Jones M, Renouf D, et al.
Cold Spring Harb Mol Case Stud
. 2018 Dec;
5(1).
PMID: 30514790
The Personalized Onco-Genomics (POG) program at BC Cancer integrates whole-genome (DNA) and RNA sequencing into practice for metastatic malignancies. We examined the subgroup of patients with metastatic non-small-cell lung cancer...