Karen M J van Loo
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Explore the profile of Karen M J van Loo including associated specialties, affiliations and a list of published articles.
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37
Citations
328
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Recent Articles
1.
Schunemann K, Hattingh R, Verhoog M, Yang D, Bak A, Peter S, et al.
J Neurophysiol
. 2025 Feb;
PMID: 40013734
Dendritic spines, small protrusions on neuronal dendrites, play a crucial role in brain function by changing shape and size in response to neural activity. So far, analysis of dendritic spines...
2.
Bak A, Schmied K, Jakob M, Bedogni F, Squire O, Gittel B, et al.
J Neurophysiol
. 2024 Aug;
132(3):1038-1055.
PMID: 39140591
Murine organotypic brain slice cultures have been widely used in neuroscientific research and are offering the opportunity to study neuronal function under normal and disease conditions. Despite the broad application,...
3.
Bak A, Koch H, van Loo K, Schmied K, Gittel B, Weber Y, et al.
J Neurosci Methods
. 2024 Jan;
404:110055.
PMID: 38184112
The investigation of the human brain at cellular and microcircuit level remains challenging due to the fragile viability of neuronal tissue, inter- and intra-variability of the samples and limited availability...
4.
Galvis-Montes D, van Loo K, van Waardenberg A, Surges R, Schoch S, Becker A, et al.
Sci Rep
. 2023 Dec;
13(1):22187.
PMID: 38092829
Transient brain insults including status epilepticus (SE) can initiate a process termed 'epileptogenesis' that results in chronic temporal lobe epilepsy. As a consequence, the entire tri-synaptic circuit of the hippocampus...
5.
Gallus M, Roll W, Dik A, Barca C, Zinnhardt B, Hicking G, et al.
Sci Adv
. 2023 Jun;
9(23):eabq7595.
PMID: 37294768
Autoimmune limbic encephalitis (ALE) presents with new-onset mesial temporal lobe seizures, progressive memory disturbance, and other behavioral and cognitive changes. CD8 T cells are considered to play a key role...
6.
Vana N, van Loo K, van Waardenberg A, Tiessen M, Cases-Cunillera S, Sun W, et al.
Glia
. 2023 May;
71(9):2210-2233.
PMID: 37226895
Oligodendrocyte precursor cells (OPCs) generate oligodendrocytes, a process that may be tuned by neuronal activity, possibly via synaptic connections to OPCs. However, a developmental role of synaptic signaling to OPCs...
7.
Kyriazi M, Muller P, Pitsch J, van Loo K, Quatraccioni A, Opitz T, et al.
Dev Neurosci
. 2022 Dec;
45(2):53-65.
PMID: 36538906
Gangliogliomas (GGs), composed of dysmorphic neurons and neoplastic astroglia, represent the most frequent tumor entity associated with chronic recurrent epileptic seizures. So far, a systematic analysis of potential differences in...
8.
van Loo K, Carvill G, Becker A, Conboy K, Goldman A, Kobow K, et al.
Nat Rev Neurol
. 2022 Jul;
18(9):530-543.
PMID: 35859062
An increasing number of epilepsies are being attributed to variants in genes with epigenetic functions. The products of these genes include factors that regulate the structure and function of chromatin...
9.
Silvennoinen K, Gawel K, Tsortouktzidis D, Pitsch J, Alhusaini S, van Loo K, et al.
Acta Neuropathol
. 2022 May;
144(1):107-127.
PMID: 35551471
Mesial temporal lobe epilepsy with hippocampal sclerosis and a history of febrile seizures is associated with common variation at rs7587026, located in the promoter region of SCN1A. We sought to...
10.
Tsortouktzidis D, Troscher A, Schulz H, Opitz T, Schoch S, Becker A, et al.
Front Mol Neurosci
. 2022 Jan;
14:667143.
PMID: 35069110
Precise genome editing in combination with viral delivery systems provides a valuable tool for neuroscience research. Traditionally, the role of genes in neuronal circuits has been addressed by overexpression or...