Karen M Ashe
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Explore the profile of Karen M Ashe including associated specialties, affiliations and a list of published articles.
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13
Citations
283
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Recent Articles
1.
Ashe K, Geller A, Pendharkar J, Pbert L, Crawford S, Clark M, et al.
Am J Prev Med
. 2021 Feb;
60(5):711-715.
PMID: 33632652
Introduction: Clinical guidelines support physician intervention consistent with the Ask, Advise, Assess, Assist, Arrange framework for adults who have obesity. However, weight management counseling curricula vary across medical schools. It...
2.
Geller A, Ockene J, Kulkarni M, Churchill L, Frisard C, Okuliar C, et al.
Am J Prev Med
. 2018 Oct;
55(5):e139-e145.
PMID: 30342638
Introduction: Primary care providers, using brief counseling, can help patients increase motivation to initiate or maintain weight loss, improve diet, and increase physical activity. However, no prior studies have examined...
3.
Ashe K, Lapane K
J Womens Health (Larchmt)
. 2017 Nov;
27(5):651-658.
PMID: 29182494
Background: Women are disproportionately affected by both obesity and food insecurity. Food insecurity occurs when there is limited ability to acquire adequate foods. It is unknown whether social support can...
4.
Ockene J, Ashe K, Hayes R, Churchill L, Crawford S, Geller A, et al.
Contemp Clin Trials
. 2017 Nov;
64:58-66.
PMID: 29128651
Physicians have an important role addressing the obesity epidemic. Lack of adequate teaching to provide weight management counseling (WMC) is cited as a reason for limited treatment. National guidelines have...
5.
Ashe K, Budman E, Bangari D, Siegel C, Nietupski J, Wang B, et al.
Mol Med
. 2015 May;
21:389-99.
PMID: 25938659
Fabry disease, an X-linked glycosphingolipid storage disorder, is caused by the deficient activity of α-galactosidase A (α-Gal A). This results in the lysosomal accumulation in various cell types of its...
6.
Bangari D, Ashe K, Desnick R, Maloney C, Lydon J, Piepenhagen P, et al.
Am J Pathol
. 2015 Jan;
185(3):651-65.
PMID: 25553976
Fabry disease is an X-linked lysosomal storage disease caused by deficient activity of α-galactosidase A and the resultant systemic accumulation of globotrioasylceramide (GL-3) and related glycolipids. α-Galactosidase A gene knockout...
7.
Bu J, Ashe K, Bringas J, Marshall J, Dodge J, Cabrera-Salazar M, et al.
Mol Ther
. 2012 Jul;
20(10):1893-901.
PMID: 22828503
Niemann-Pick disease Type A (NPA) is a neuronopathic lysosomal storage disease (LSD) caused by the loss of acid sphingomyelinase (ASM). The goals of the current study are to ascertain the...
8.
Nietupski J, Pacheco J, Chuang W, Maratea K, Li L, Foley J, et al.
Mol Genet Metab
. 2012 Feb;
105(4):621-8.
PMID: 22366055
Niemann Pick type C (NPC) disease is a progressive neurodegenerative disease caused by mutations in NPC1 or NPC2, the gene products of which are involved in cholesterol transport in late...
9.
Ashe K, Bangari D, Li L, Cabrera-Salazar M, Bercury S, Nietupski J, et al.
PLoS One
. 2011 Jul;
6(6):e21758.
PMID: 21738789
The neuropathic glycosphingolipidoses are a subgroup of lysosomal storage disorders for which there are no effective therapies. A potential approach is substrate reduction therapy using inhibitors of glucosylceramide synthase (GCS)...
10.
Nietupski J, Hurlbut G, Ziegler R, Chu Q, Hodges B, Ashe K, et al.
Mol Ther
. 2011 Jun;
19(11):1999-2011.
PMID: 21712814
In mice, liver-restricted expression of lysosomal enzymes from adeno-associated viral serotype 8 (AAV8) vectors results in reduced antibodies to the expressed proteins. To ask whether this result might translate to...