Karen G Dowell
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Explore the profile of Karen G Dowell including associated specialties, affiliations and a list of published articles.
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12
Citations
637
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Recent Articles
1.
Quardokus E, Saunders D, McDonough E, Hickey J, Werlein C, Surrette C, et al.
Nat Methods
. 2023 Jul;
20(8):1174-1178.
PMID: 37468619
Multiplexed antibody-based imaging enables the detailed characterization of molecular and cellular organization in tissues. Advances in the field now allow high-parameter data collection (>60 targets); however, considerable expertise and capital...
2.
Cheng H, Dowell K, Bailey-Kellogg C, Goods B, Love J, Ferrari G, et al.
Retrovirology
. 2021 Oct;
18(1):35.
PMID: 34717659
Background: The critical role of antibody Fc-mediated effector functions in immune defense has been widely reported in various viral infections. These effector functions confer cellular responses through engagement with innate...
3.
Wardwell-Swanson J, Suzuki M, Dowell K, Bieri M, Thoma E, Agarkova I, et al.
SLAS Discov
. 2020 Jun;
25(7):709-722.
PMID: 32484408
Three-dimensional (3D) spheroid models are rapidly gaining favor for drug discovery applications due to their improved morphological characteristics, cellular complexity, long lifespan in culture, and higher physiological relevance relative to...
4.
Alter G, Dowell K, Brown E, Suscovich T, Mikhailova A, Mahan A, et al.
Mol Syst Biol
. 2018 Mar;
14(3):e7881.
PMID: 29581149
Defining correlates of immunity by comprehensively interrogating the extensive biological diversity in naturally or experimentally protected subjects may provide insights critical for guiding the development of effective vaccines and antibody-based...
5.
Brown E, Dowell K, Boesch A, Normandin E, Mahan A, Chu T, et al.
J Immunol Methods
. 2017 Feb;
443:33-44.
PMID: 28163018
Antibodies are widely considered to be a frequent primary and often mechanistic correlate of protection of approved vaccines; thus evaluating the antibody response is of critical importance in attempting to...
6.
Huang Y, Ferrari G, Alter G, Forthal D, Kappes J, Lewis G, et al.
J Immunol
. 2016 Dec;
197(12):4603-4612.
PMID: 27913647
Diverse Ab effector functions mediated by the Fc domain have been commonly associated with reduced risk of infection in a growing number of nonhuman primate and human clinical studies. This...
7.
Vaccari M, Gordon S, Fourati S, Schifanella L, Liyanage N, Cameron M, et al.
Nat Med
. 2016 Oct;
22(10):1192.
PMID: 27711066
No abstract available.
8.
Vaccari M, Gordon S, Fourati S, Schifanella L, Liyanage N, Cameron M, et al.
Nat Med
. 2016 May;
22(7):762-70.
PMID: 27239761
A recombinant vaccine containing Aventis Pasteur's canarypox vector (ALVAC)-HIV and gp120 alum decreased the risk of HIV acquisition in the RV144 vaccine trial. The substitution of alum with the more...
9.
Ackerman M, Mikhailova A, Brown E, Dowell K, Walker B, Bailey-Kellogg C, et al.
PLoS Pathog
. 2016 Jan;
12(1):e1005315.
PMID: 26745376
Elite controllers (ECs) represent a unique model of a functional cure for HIV-1 infection as these individuals develop HIV-specific immunity able to persistently suppress viremia. Because accumulating evidence suggests that...
10.
Dowell K, Simons A, Bai H, Kell B, Wang Z, Yun K, et al.
Stem Cells
. 2013 Dec;
32(5):1161-72.
PMID: 24307629
Embryonic stem cells (ESCs), characterized by their ability to both self-renew and differentiate into multiple cell lineages, are a powerful model for biomedical research and developmental biology. Human and mouse...