Karan J Abraham
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Explore the profile of Karan J Abraham including associated specialties, affiliations and a list of published articles.
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9
Citations
280
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Recent Articles
1.
Khosraviani N, Abraham K, Chan J, Mekhail K
STAR Protoc
. 2022 Sep;
3(4):101734.
PMID: 36178790
Modulating R-loop triplex nucleic acid structures reveals their roles across the genome. However, common approaches cannot ascribe functions to R-loops in a locus-associated manner. This protocol presents the use of...
2.
Abraham K, Khosraviani N, Chan J, Gorthi A, Samman A, Zhao D, et al.
Nature
. 2020 Jul;
585(7824):298-302.
PMID: 32669707
Proteins are manufactured by ribosomes-macromolecular complexes of protein and RNA molecules that are assembled within major nuclear compartments called nucleoli. Existing models suggest that RNA polymerases I and III (Pol...
3.
Ostrowski L, Hall A, Szafranski K, Oshidari R, Abraham K, Chan J, et al.
Commun Biol
. 2018 Nov;
1:187.
PMID: 30417124
Ribosomal DNA (rDNA) repeat instability and protein aggregation are thought to be two major and independent drivers of cellular aging. Pbp1, the yeast ortholog of human ATXN2, maintains rDNA repeat...
4.
Oshidari R, Strecker J, Chung D, Abraham K, Chan J, Damaren C, et al.
Nat Commun
. 2018 Jul;
9(1):2567.
PMID: 29967403
Damaged DNA shows increased mobility, which can promote interactions with repair-conducive nuclear pore complexes (NPCs). This apparently random mobility is paradoxically abrogated upon disruption of microtubules or kinesins, factors that...
5.
Abraham K, Chan J, Salvi J, Ho B, Hall A, Vidya E, et al.
Nucleic Acids Res
. 2016 Aug;
44(18):8870-8884.
PMID: 27574117
Dietary calorie restriction is a broadly acting intervention that extends the lifespan of various organisms from yeast to mammals. On another front, magnesium (Mg) is an essential biological metal critical...
6.
Abraham K, Ostrowski L, Mekhail K
J Mol Biol
. 2016 Aug;
429(21):3196-3214.
PMID: 27561708
Calorie restriction (CR) is a broadly effective environmental intervention that extends life by operating through numerous biological processes. Here, we discuss how non-coding RNA (ncRNA) molecules act as mediators and...
7.
Abraham K, Zhang X, Vidal R, Pare G, Feilotter H, Tron V
Am J Pathol
. 2016 Feb;
186(4):1025-35.
PMID: 26877261
Dysfunction of key miRNA pathways regulating basic cellular processes is a common driver of many cancers. However, the biological roles and/or clinical applications of such pathways in Merkel cell carcinoma...
8.
Perinuclear tethers license telomeric DSBs for a broad kinesin- and NPC-dependent DNA repair process
Chung D, Chan J, Strecker J, Zhang W, Ebrahimi-Ardebili S, Lu T, et al.
Nat Commun
. 2015 Jul;
6:7742.
PMID: 26205667
DNA double-strand breaks (DSBs) are often targeted to nuclear pore complexes (NPCs) for repair. How targeting is achieved and the DNA repair pathways involved in this process remain unclear. Here,...
9.
Szafranski K, Abraham K, Mekhail K
Front Genet
. 2015 Mar;
6:87.
PMID: 25806046
Declining brain and neurobiological function is arguably one of the most common features of human aging. The study of conserved aging processes as well as the characterization of various neurodegenerative...