Kanyile K Ncokazi
Overview
Explore the profile of Kanyile K Ncokazi including associated specialties, affiliations and a list of published articles.
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7
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304
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Recent Articles
1.
Combrinck J, Mabotha T, Ncokazi K, Ambele M, Taylor D, Smith P, et al.
ACS Chem Biol
. 2012 Oct;
8(1):133-7.
PMID: 23043646
By using cell fractionation and measurement of Fe(III)heme-pyridine, the antimalarial chloroquine (CQ) has been shown to cause a dose-dependent decrease in hemozoin and concomitant increase in toxic free heme in...
2.
Dubar F, Egan T, Pradines B, Kuter D, Ncokazi K, Forge D, et al.
ACS Chem Biol
. 2010 Dec;
6(3):275-87.
PMID: 21162558
Inhibition of hemozoin biocrystallization is considered the main mechanism of action of 4-aminoquinoline antimalarials including chloroquine (CQ) but cannot fully explain the activity of ferroquine (FQ) which has been related...
3.
Hoang A, Ncokazi K, de Villiers K, Wright D, Egan T
Dalton Trans
. 2010 Jan;
39(5):1235-44.
PMID: 20104349
The mechanism of formation of haemozoin, a detoxification by-product of several blood-feeding organisms including malaria parasites, has been a subject of debate; however, recent studies suggest that neutral lipids may...
4.
Egan T, Chen J, de Villiers K, Mabotha T, Naidoo K, Ncokazi K, et al.
FEBS Lett
. 2006 Sep;
580(21):5105-10.
PMID: 16956610
Several blood-feeding organisms, including the malaria parasite detoxify haem released from host haemoglobin by conversion to the insoluble crystalline ferriprotoporphyrin IX dimer known as haemozoin. To date the mechanism of...
5.
Egan T, Ncokazi K
J Inorg Biochem
. 2005 Jun;
99(7):1532-9.
PMID: 15927260
The strength of inhibition of beta-hematin (synthetic hemozoin or malaria pigment) formation by the quinoline antimalarial drugs chloroquine, amodiaquine, quinidine and quinine has been investigated as a function of incubation...
6.
Ncokazi K, Egan T
Anal Biochem
. 2005 Mar;
338(2):306-19.
PMID: 15745752
Antimalarial drugs such as chloroquine are believed to act by inhibiting hemozoin formation in the food vacuole of the malaria parasite. We have developed a new assay for measuring and...
7.
Egan T, Ncokazi K
J Inorg Biochem
. 2003 Dec;
98(1):144-52.
PMID: 14659643
Enthalpy-entropy compensation in the interaction of quinoline antimalarials with ferriprotoporphyrin IX (Fe(III)PPIX) in 40% aqueous dimethyl sulfoxide (DMSO) has been compared with that in pure aqueous solution. The data indicate...