Kamil A Kobak
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Explore the profile of Kamil A Kobak including associated specialties, affiliations and a list of published articles.
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12
Citations
85
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Recent Articles
1.
Zarzycka W, Kobak K, King C, Peelor 3rd F, Miller B, Chiao Y
Geroscience
. 2024 Oct;
PMID: 39379739
The mechanistic target of rapamycin complex 1 (mTORC1) has a major impact on aging by regulation of proteostasis. It is well established that mTORC1 signaling is hyperactivated with aging and...
2.
Kobak K, Batushansky A, Jopkiewicz A, Peelor 3rd F, Kinter M, Miller B, et al.
Osteoarthr Cartil Open
. 2024 Jul;
6(3):100495.
PMID: 39040627
Objective: To identify factors contributing to sex-differences in OA risk by evaluating the short-term effect of high-fat (HF) diet on sex-specific changes in cartilage cell proliferation, ribosomal biogenesis, and targeted...
3.
Zarzycka W, Kobak K, King C, Peelor F, Miller B, Chiao Y
bioRxiv
. 2024 May;
PMID: 38798509
The mechanistic target of rapamycin complex 1 (mTORC1) has a major impact on aging by regulation of proteostasis. It is well established that mTORC1 signaling is hyperactivated with aging and...
4.
Kumiega E, Kobak K, Noszczyk-Nowak A, Kasztura M
BMC Vet Res
. 2024 May;
20(1):210.
PMID: 38762716
Background: Myxomatous mitral valve disease (MMVD) is the most common acquired cardiovascular disease in small breed dogs. In contrast to human patients with heart failure (HF), iron deficiency (ID) prevalence...
5.
Semaglutide in Heart Failure With Preserved Ejection Fraction: Benefits Above and Beyond Weight Loss
Kobak K, Chiao Y
JACC Basic Transl Sci
. 2023 Dec;
8(10):1315-1317.
PMID: 38094694
No abstract available.
6.
Chakraborty A, Kooiker K, Kobak K, Cheng Y, Lee C, Razumova M, et al.
bioRxiv
. 2023 Jul;
PMID: 37398078
Diastolic dysfunction is a key feature of the aging heart. We have shown that late-life treatment with mTOR inhibitor, rapamycin, reverses age-related diastolic dysfunction in mice but the molecular mechanisms...
7.
Kobak K, Batushansky A, Borowik A, Lopes E, Peelor Iii F, Donovan E, et al.
Function (Oxf)
. 2022 Apr;
3(2):zqac008.
PMID: 35399495
Targeting chondrocyte dynamics is a strategy for slowing osteoarthritis progression during aging. We describe a stable-isotope method using in vivo deuterium oxide labeling and mass spectrometry to measure protein concentration,...
8.
Kobak K, Lawrence M, Pharaoh G, Borowik A, Peelor 3rd F, Shipman P, et al.
J Cachexia Sarcopenia Muscle
. 2021 Aug;
12(6):1764-1775.
PMID: 34418329
Background: Ageing and cachexia cause a loss of muscle mass over time, indicating that protein breakdown exceeds protein synthesis. Deuterium oxide (D O) is used for studies of protein turnover...
9.
Abbott C, Lawrence M, Kobak K, Lopes E, Peelor 3rd F, Donald E, et al.
Function (Oxf)
. 2021 Jun;
2(4):zqab028.
PMID: 34124684
Age-related deterioration in turnover of collagen proteins accelerates extracellular matrix fibrosis and hinders adaptation to external stimuli. This project sought to understand factors that increase skeletal muscle fibrosis with age...
10.
Kobak K, Franczuk P, Schubert J, Dziegala M, Kasztura M, Tkaczyszyn M, et al.
Cells
. 2021 Apr;
10(4).
PMID: 33917391
Cardiac fibroblasts and cardiomyocytes are the main cells involved in the pathophysiology of myocarditis (MCD). These cells are especially sensitive to changes in iron homeostasis, which is extremely important for...