Kaitlin Kiernan
Overview
Explore the profile of Kaitlin Kiernan including associated specialties, affiliations and a list of published articles.
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7
Citations
322
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0
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Recent Articles
1.
Kiernan K, Alwarawrah Y, Nichols A, Danzaki K, MacIver N
Sci Rep
. 2024 Feb;
14(1):4331.
PMID: 38383709
Insulin and insulin-like growth factor 1 (IGF-1) are metabolic hormones with known effects on CD4 T cells through insulin receptor (IR) and IGF-1 receptor (IGF-1R) signaling. Here, we describe specific...
2.
Kiernan K, Nichols A, Alwarawrah Y, MacIver N
PLoS One
. 2023 Jun;
18(6):e0286470.
PMID: 37276236
Background/objectives: Leptin is an adipokine secreted in proportion to adipocyte mass and is therefore increased in obesity. Leptin signaling has been shown to directly promote inflammatory T helper 1 (Th1)...
3.
Kiernan K, MacIver N
Front Immunol
. 2021 Feb;
11:622468.
PMID: 33584724
Leptin is a critical mediator of the immune response to changes in overall nutrition. Leptin is produced by adipocytes in proportion to adipose tissue mass and is therefore increased in...
4.
Alwarawrah Y, Nichols A, Green W, Eisner W, Kiernan K, Warren J, et al.
Int J Obes (Lond)
. 2020 Oct;
44(12):2419-2429.
PMID: 33037327
Background: Obesity is associated with impaired primary and secondary immune responses to influenza infection, with T cells playing a critical role. T-cell function is highly influenced by the cellular metabolic...
5.
Kiernan K, MacIver N
Trends Endocrinol Metab
. 2019 Nov;
31(1):1-2.
PMID: 31767267
In their recent study, Nicholas et al. challenge the current dogma that T cell inflammation must be fueled by glycolysis and demonstrate a novel metabolic mechanism for Th17 inflammation in...
6.
Kiernan K, MacIver N
Immunity
. 2018 Jul;
49(1):6-8.
PMID: 30021147
In this issue of Immunity, Šestan et al. (2018) show that viral-induced inflammation leads to insulin resistance in skeletal muscle, followed by compensatory hyperinsulinemia, which promotes the anti-viral effector response...
7.
Alwarawrah Y, Kiernan K, MacIver N
Front Immunol
. 2018 Jun;
9:1055.
PMID: 29868016
Immune cell function and metabolism are closely linked. Many studies have now clearly demonstrated that alterations in cellular metabolism influence immune cell function and that, conversely, immune cell function determines...