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Kaitavjeet Chowdhary

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Articles 15
Citations 363
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Recent Articles
1.
Chowdhary K, Leon J, Mathis D, Benoist C
Proc Natl Acad Sci U S A . 2024 Aug; 121(36):e2411301121. PMID: 39196621
Vertebrate cell identity depends on the combined activity of scores of transcription factors (TF). While TFs have often been studied in isolation, a systematic perspective on their integration has been...
2.
Ramanan D, Chowdhary K, Candeias S, Sassone-Corsi M, Gelineau A, Mathis D, et al.
Proc Natl Acad Sci U S A . 2023 Dec; 120(50):e2311566120. PMID: 38064511
Foxp3 regulatory T cells (Tregs) in the colon are key to promoting peaceful coexistence with symbiotic microbes. Differentiated in either thymic or peripheral locations, and modulated by microbes and other...
3.
Leon J, Chowdhary K, Zhang W, Ramirez R, Andre I, Hur S, et al.
Cell Rep . 2023 Aug; 42(8):113018. PMID: 37605532
Mutations of the transcription factor FoxP3 in patients with "IPEX" (immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome) disrupt regulatory T cells (Treg), causing an array of multiorgan autoimmunity. To understand the...
4.
Ramanan D, Pratama A, Zhu Y, Venezia O, Sassone-Corsi M, Chowdhary K, et al.
Nat Rev Immunol . 2023 Jun; 23(11):749-762. PMID: 37316560
Regulatory T cells (T cells) are key players in ensuring a peaceful coexistence with microorganisms and food antigens at intestinal borders. Startling new information has appeared in recent years on...
5.
Ramanan D, Chowdhary K, Candeias S, Sassone-Corsi M, Mathis D, Benoist C
bioRxiv . 2023 Jun; PMID: 37292878
Foxp3 regulatory T cells (Tregs) in the colon are key to promoting peaceful co-existence with symbiotic microbes. Differentiated in either thymic or peripheral locations, and modulated by microbes and other...
6.
Chowdhary K, Benoist C
Trends Immunol . 2023 May; 44(7):530-541. PMID: 37258360
Specific combinations of transcription factors (TFs) control the gene expression programs that underlie specialized immune responses. Previous models of TF function in immunocytes had restricted each TF to a single...
7.
Olejnik J, Leon J, Michelson D, Chowdhary K, Galvan-Pena S, Benoist C, et al.
Pathogens . 2023 Feb; 12(2). PMID: 36839614
Technologies that facilitate the bulk sequencing of small numbers of cells as well as single-cell RNA sequencing (scRNA-seq) have aided greatly in the study of viruses as these analyses can...
8.
Ramirez R, Chowdhary K, Leon J, Mathis D, Benoist C
Sci Immunol . 2022 Jan; 7(67):eabj9836. PMID: 35030035
Gene expression programs are specified by higher-order chromatin structure and enhancer-promoter loops (EPLs). T regulatory cell (T) identity is dominantly specified by the transcription factor (TF) FoxP3, whose mechanism of...
9.
Leon J, Michelson D, Olejnik J, Chowdhary K, Oh H, Hume A, et al.
Proc Natl Acad Sci U S A . 2021 Dec; 119(1). PMID: 34969849
Infection by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) provokes a potentially fatal pneumonia with multiorgan failure, and high systemic inflammation. To gain mechanistic insight and ferret out the root of...
10.
Galvan-Pena S, Leon J, Chowdhary K, Michelson D, Vijaykumar B, Yang L, et al.
Proc Natl Acad Sci U S A . 2021 Aug; 118(37). PMID: 34433692
The hallmark of severe COVID-19 is an uncontrolled inflammatory response, resulting from poorly understood immunological dysfunction. We hypothesized that perturbations in FoxP3 T regulatory cells (Treg), key enforcers of immune...