Kaisa E Happonen
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Explore the profile of Kaisa E Happonen including associated specialties, affiliations and a list of published articles.
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20
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Recent Articles
11.
Yla-Anttila P, Mikkonen E, Happonen K, Holland P, Ueno T, Simonsen A, et al.
Autophagy
. 2015 Sep;
11(10):1833-48.
PMID: 26325487
RAB24 belongs to a family of small GTPases and has been implicated to function in autophagy. Here we confirm the intracellular localization of RAB24 to autophagic vacuoles with immuno electron...
12.
Korpetinou A, Skandalis S, Moustakas A, Happonen K, Tveit H, Prydz K, et al.
PLoS One
. 2013 Nov;
8(10):e78157.
PMID: 24205138
Serglycin is a proteoglycan expressed by some malignant cells. It promotes metastasis and protects some tumor cells from complement system attack. In the present study, we show for the first...
13.
Happonen K, Saxne T, Jacobsson L, Sturfelt G, Ronnelid J, Mollnes T, et al.
J Rheumatol
. 2013 Nov;
40(12):2001-5.
PMID: 24187101
Objective: To investigate biomarker patterns in rheumatoid arthritis (RA) with extraarticular manifestations. Methods: Cartilage oligomeric matrix protein (COMP), COMP-C3b, and soluble terminal complement complexes (sTCC) were measured by ELISA. Results:...
14.
Nandakumar K, Collin M, Happonen K, Croxford A, Lundstrom S, Zubarev R, et al.
Proc Natl Acad Sci U S A
. 2013 May;
110(25):10252-7.
PMID: 23671108
A unique anti-inflammatory property of IgG, independent of antigen specificity, is described. IgG with modification of the heavy-chain glycan on asparagine 297 by the streptococcal enzyme endo-β-N-acetylglucosaminidase (EndoS) induced a...
15.
Happonen K, Heinegard D, Saxne T, Blom A
Immunobiology
. 2012 Sep;
217(11):1088-96.
PMID: 22964234
Rheumatoid arthritis (RA) is a highly disabling disease affecting all structures of the joint. Understanding the pathology behind the development of RA is essential for developing targeted therapeutic strategies as...
16.
Happonen K, Melin Furst C, Saxne T, Heinegard D, Blom A
J Biol Chem
. 2012 Jan;
287(11):8092-100.
PMID: 22267731
PRELP is a 58-kDa proteoglycan found in a variety of extracellular matrices, including cartilage and at several basement membranes. In rheumatoid arthritis (RA), the cartilage tissue is destroyed and fragmented...
17.
Happonen K, Saxne T, Geborek P, Andersson M, Bengtsson A, Hesselstrand R, et al.
Arthritis Res Ther
. 2012 Jan;
14(1):R15.
PMID: 22264230
Introduction: Cartilage oligomeric matrix protein (COMP) is found at elevated concentrations in sera of patients with joint diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). We recently showed that...
18.
Skliris A, Happonen K, Terpos E, Labropoulou V, Borset M, Heinegard D, et al.
Eur J Immunol
. 2011 Jan;
41(2):437-49.
PMID: 21268013
Serglycin (SG) is a proteoglycan expressed by hematopoietic cells and is constitutively secreted by multiple myeloma (MM) cells. SG participates in the regulation of various inflammatory events. We found that...
19.
Happonen K, Saxne T, Aspberg A, Morgelin M, Heinegard D, Blom A
Arthritis Rheum
. 2010 Aug;
62(12):3574-83.
PMID: 20737467
Objective: Cartilage oligomeric matrix protein (COMP) is a structural component of cartilage, where it catalyzes collagen fibrillogenesis. Elevated amounts of COMP are found in serum during increased turnover of cartilage...
20.
Happonen K, Sjoberg A, Morgelin M, Heinegard D, Blom A
J Immunol
. 2009 Jan;
182(3):1518-25.
PMID: 19155499
Components derived from cartilage have been suggested to maintain the inflammation in joints in arthritis. Small leucine-rich repeat proteins (SLRPs) are structural components of cartilage important in organizing the meshwork...