Kai Harkonen
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Explore the profile of Kai Harkonen including associated specialties, affiliations and a list of published articles.
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11
Citations
245
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Recent Articles
1.
Matilainen J, Berg V, Vaittinen M, Impola U, Mustonen A, Mannisto V, et al.
J Transl Med
. 2024 Jul;
22(1):623.
PMID: 38965596
Background: Obesity is a worldwide epidemic characterized by adipose tissue (AT) inflammation. AT is also a source of extracellular vesicles (EVs) that have recently been implicated in disorders related to...
2.
Ilvonen P, Pusa R, Harkonen K, Laitinen S, Impola U
J Extracell Biol
. 2024 Jun;
3(1):e130.
PMID: 38938679
Blood-derived extracellular vesicles (EVs) hold great therapeutic potential. As blood contains mixed EV populations, it is challenging to study EVs originating from different cells separately. Blood cell concentrates manufactured in...
3.
Microscopic characterization reveals the diversity of EVs secreted by GFP-HAS3 expressing MCF7 cells
Capra J, Harkonen K, Kyykallio H, Vihinen H, Jokitalo E, Rilla K
Eur J Cell Biol
. 2022 May;
101(3):151235.
PMID: 35569384
We have shown the connection of hyaluronan synthesis activity with the enhanced shedding of extracellular vesicles, but detailed morphological analysis of those hyaluronan-induced EVs is still missing. In this study...
4.
Arasu U, Deen A, Pasonen-Seppanen S, Heikkinen S, Lalowski M, Karna R, et al.
Cell Mol Life Sci
. 2019 Dec;
77(20):4093-4115.
PMID: 31820036
Intercellular communication is fundamental to the survival and maintenance of all multicellular systems, whereas dysregulation of communication pathways can drive cancer progression. Extracellular vesicles (EVs) are mediators of cell-to-cell communication...
5.
Felszeghy S, Pasonen-Seppanen S, Koskela A, Nieminen P, Harkonen K, Paldanius K, et al.
BMC Med Educ
. 2019 Jul;
19(1):273.
PMID: 31331319
Background: Human morphology is a critical component of dental and medical graduate training. Innovations in basic science teaching methods are needed to keep up with an ever-changing landscape of technology....
6.
Harkonen K, Oikari S, Kyykallio H, Capra J, Hakkola S, Ketola K, et al.
Cells
. 2019 Mar;
8(3).
PMID: 30909497
CD44 is a multifunctional adhesion molecule typically upregulated in malignant, inflamed and injured tissues. Due to its ability to bind multiple ligands present in the tumor microenvironment, it promotes multiple...
7.
Arasu U, Harkonen K, Koistinen A, Rilla K
Exp Cell Res
. 2019 Feb;
376(2):149-158.
PMID: 30763584
Extracellular vesicles (EVs) and their interactions with recipient cells constitute a rapidly growing research area. However, due to the limitations in current methodologies, the mechanisms of these interactions are still...
8.
Rilla K, Mustonen A, Arasu U, Harkonen K, Matilainen J, Nieminen P
Matrix Biol
. 2017 Oct;
75-76:201-219.
PMID: 29066152
Extracellular vesicles (EV) are small plasma membrane-derived particles released into the extracellular space by virtually all cell types. Recently, EV have received increased interest because of their capability to carry...
9.
Arasu U, Karna R, Harkonen K, Oikari S, Koistinen A, Kroger H, et al.
Matrix Biol
. 2017 May;
64:54-68.
PMID: 28483644
Extracellular vesicles (EVs) secreted by stem cells are potential factors mediating tissue regeneration. They travel from bone marrow stem cells into damaged tissues, suggesting that they can repair tissue injuries...
10.
Koistinen V, Harkonen K, Karna R, Arasu U, Oikari S, Rilla K
Matrix Biol
. 2017 Jan;
63:38-54.
PMID: 28043889
The mesothelium is a membrane that forms the lining of several body cavities. It is composed of simple squamous mesothelial cells that secrete a glycosaminoglycan-rich lubricating fluid between inner organs....