Kaare M Gautvik
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Explore the profile of Kaare M Gautvik including associated specialties, affiliations and a list of published articles.
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47
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1513
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Recent Articles
11.
Zheng J, Maerz W, Gergei I, Kleber M, Drechsler C, Wanner C, et al.
J Bone Miner Res
. 2019 Jun;
34(10):1824-1836.
PMID: 31170332
In bone, sclerostin is mainly osteocyte-derived and plays an important local role in adaptive responses to mechanical loading. Whether circulating levels of sclerostin also play a functional role is currently...
12.
Karabegovic I, Maas S, Medina-Gomez C, Zrimsek M, Reppe S, Gautvik K, et al.
Int J Mol Sci
. 2017 Dec;
18(12).
PMID: 29186852
MicroRNAs (miRNAs) are small non-coding RNA molecules that post-transcriptionally regulate the translation of messenger RNAs. Given the crucial role of miRNAs in gene expression, genetic variants within miRNA-related sequences may...
13.
Alonso N, Estrada K, Albagha O, Herrera L, Reppe S, Olstad O, et al.
Ann Rheum Dis
. 2017 Nov;
77(3):378-385.
PMID: 29170203
Objectives: To identify genetic determinants of susceptibility to clinical vertebral fractures, which is an important complication of osteoporosis. Methods: Here we conduct a genome-wide association study in 1553 postmenopausal women...
14.
Medina-Gomez C, Kemp J, Dimou N, Kreiner E, Chesi A, Zemel B, et al.
Nat Commun
. 2017 Jul;
8(1):121.
PMID: 28743860
Bone mineral density is known to be a heritable, polygenic trait whereas genetic variants contributing to lean mass variation remain largely unknown. We estimated the shared SNP heritability and performed...
15.
Distinct DNA methylation profiles in bone and blood of osteoporotic and healthy postmenopausal women
Reppe S, Lien T, Hsu Y, Gautvik V, Olstad O, Yu R, et al.
Epigenetics
. 2017 Jun;
12(8):674-687.
PMID: 28650214
DNA methylation affects expression of associated genes and may contribute to the missing genetic effects from genome-wide association studies of osteoporosis. To improve insight into the mechanisms of postmenopausal osteoporosis,...
16.
Reppe S, Datta H, Gautvik K
Bone
. 2017 Apr;
101:88-95.
PMID: 28450214
The skeleton is a metabolically active organ throughout life where specific bone cell activity and paracrine/endocrine factors regulate its morphogenesis and remodeling. In recent years, an increasing number of reports...
17.
Nielson C, Liu C, Smith A, Ackert-Bicknell C, Reppe S, Jakobsdottir J, et al.
J Bone Miner Res
. 2016 Aug;
31(12):2085-2097.
PMID: 27476799
Genome-wide association studies (GWASs) have revealed numerous loci for areal bone mineral density (aBMD). We completed the first GWAS meta-analysis (n = 15,275) of lumbar spine volumetric BMD (vBMD) measured...
18.
Reppe S, Datta H, Gautvik K
Curr Genomics
. 2016 Mar;
16(6):384-92.
PMID: 27019613
DNA methylation in eukaryotes invokes heritable alterations of the of the cytosine base in DNA without changing the underlying genomic DNA sequence. DNA methylation may be modified by environmental exposures...
19.
Reppe S, Wang Y, Thompson W, McEvoy L, Schork A, Zuber V, et al.
PLoS One
. 2015 Dec;
10(12):e0144531.
PMID: 26695485
Bone Mineral Density (BMD) is a highly heritable trait, but genome-wide association studies have identified few genetic risk factors. Epidemiological studies suggest associations between BMD and several traits and diseases,...
20.
LeBlanc M, Zuber V, Andreassen B, Witoelar A, Zeng L, Bettella F, et al.
Circ Res
. 2015 Oct;
118(1):83-94.
PMID: 26487741
Rationale: Coronary artery disease (CAD) is a critical determinant of morbidity and mortality. Previous studies have identified several cardiovascular disease risk factors, which may partly arise from a shared genetic...