K W Spitzer
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Explore the profile of K W Spitzer including associated specialties, affiliations and a list of published articles.
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58
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848
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Recent Articles
1.
Kondo C, Clark R, AlJezani N, Kim T, Belke D, Banderali U, et al.
Exp Physiol
. 2018 May;
103(8):1101-1122.
PMID: 29791754
New Findings: What is the central question of this study? What are the main [Ca ] signalling pathways activated by ATP in human synovial fibroblasts? What is the main finding...
2.
Spitzer K, Skolnick R, Peercy B, Keener J, Vaughan-Jones R
J Physiol
. 2002 May;
541(Pt 1):159-67.
PMID: 12015427
Intracellular H(+) mobility was estimated in the rabbit isolated ventricular myocyte by diffusing HCl into the cell from a patch pipette, while imaging pH(i) confocally using intracellular ratiometric SNARF fluorescence....
3.
Vaughan-Jones R, Peercy B, Keener J, Spitzer K
J Physiol
. 2002 May;
541(Pt 1):139-58.
PMID: 12015426
The intrinsic mobility of intracellular H(+) ions was investigated by confocally imaging the longitudinal movement of acid inside rabbit ventricular myocytes loaded with the acetoxymethyl ester (AM) form of carboxy-seminaphthorhodafluor-1...
4.
Cordeiro J, Spitzer K, Giles W, Ershler P, Cannell M, Bridge J
J Physiol
. 2001 Apr;
531(Pt 2):301-14.
PMID: 11310434
1. The distribution and localization of Ca2+ transients and Ca2+ sparks in isolated adult rabbit Purkinje cells were examined using confocal microscopy and the Ca2+ indicator fluo-3. 2. When cells...
5.
Cordeiro J, Bridge J, Spitzer K
Cell Calcium
. 2001 Apr;
29(5):289-97.
PMID: 11292386
We investigated action potentials and Ca(2+) transients in rabbit Purkinje myocytes using whole cell patch clamp recordings and a confocal microscope. Purkinje cells were loaded with 5 microM Fluo-3/AM for...
6.
Huelsing D, Pollard A, Spitzer K
Cardiovasc Res
. 2001 Mar;
49(4):779-89.
PMID: 11230977
Objective: While several studies have demonstrated that the L-type calcium current maintains discontinuous conduction, the contribution of the transient outward current (I(to)) to conduction remains unclear. This study evaluated the...
7.
The sodium pump modulates the influence of I(Na) on [Ca2+]i transients in mouse ventricular myocytes
Su Z, Sugishita K, Ritter M, Li F, Spitzer K, Barry W
Biophys J
. 2001 Feb;
80(3):1230-7.
PMID: 11222287
To investigate whether activity of the sarcolemmal Na pump modulates the influence of sodium current on excitation-contraction (E-C) coupling, we measured [Ca(2+)](i) transients (fluo-3) in single voltage-clamped mouse ventricular myocytes...
8.
Huelsing D, Spitzer K, Pollard A
Am J Physiol Heart Circ Physiol
. 2000 Jul;
279(1):H250-9.
PMID: 10899064
Many studies suggest that early afterdepolarizations (EADs) arising from Purkinje fibers initiate triggered arrhythmias under pathological conditions. However, electrotonic interactions between Purkinje and ventricular myocytes may either facilitate or suppress...
9.
Spitzer K, Ershler P, Skolnick R, Vaughan-Jones R
Am J Physiol Heart Circ Physiol
. 2000 Apr;
278(4):H1371-82.
PMID: 10749735
This study describes the use of a microperfusion system to create rapid, large regional changes in intracellular pH (pH(i)) within single ventricular myocytes. The spatial distribution of pH(i) in single...
10.
Zaniboni M, Pollard A, Yang L, Spitzer K
Am J Physiol Heart Circ Physiol
. 2000 Mar;
278(3):H677-87.
PMID: 10710334
Single ventricular myocytes paced at a constant rate and held at a constant temperature exhibit beat-to-beat variations in action potential duration (APD). In this study we sought to quantify this...