K Spirin
Overview
Explore the profile of K Spirin including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
6
Citations
25
Followers
0
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Recent Articles
1.
Verbeek W, Spirin K, Hatta Y, Miller C, Kawamata N, Takeuchi S, et al.
Int J Oncol
. 2011 May;
10(2):257-60.
PMID: 21533370
Recently, a novel candidate tumor suppressor gene, DPC 4/SMAD 4, has been implicated in the development of pancreatic cancers. Its location at human chromosome 18q21 prompted us to investigate this...
2.
Spirin K, Simpson J, Miller C, Koeffler H
Int J Oncol
. 2011 Apr;
11(4):737-44.
PMID: 21528268
Cell cycle regulators have recently been implicated in oncogenic transformation of cells, including the cyclins active in the G1 phase of the cell cycle and their respective cyclin-dependent kinases (CDK)...
3.
Hatta Y, Spirin K, Tasaka T, Morosetti R, Said J, Yamada Y, et al.
Br J Haematol
. 1997 Dec;
99(3):665-7.
PMID: 9401081
p18INK4C, a cyclin-dependent kinase inhibitor, is a homologue of p15INK4B and p16INK4A which are frequently altered in a variety of malignancies. We searched for structural alterations of the p18INK4C gene...
4.
Shiohara M, Spirin K, Said J, Gombart A, Nakamaki T, Takeuchi S, et al.
Leukemia
. 1996 Dec;
10(12):1897-900.
PMID: 8946928
Cyclin-dependent kinase inhibitors (CDKIs) can be classified into two groups based on the structure of the proteins. One group includes the p21 (CIP1, WAF1, CAP20), p27 (Kip1), and p57 (Kip2)...
5.
Ishiguro A, Spirin K, Shiohara M, Tobler A, Norton J, Rigolet M, et al.
Leuk Res
. 1995 Dec;
19(12):989-96.
PMID: 8632670
Helix-loop-helix (HLH) transcription factors are involved in cellular growth and differentiation. The Id (inhibitor of DNA binding and differentiation) HLH proteins, in a dominantly negative fashion, regulate transcriptional activities of...
6.
Akashi M, Hachiya M, Osawa Y, Spirin K, Suzuki G, Koeffler H
J Biol Chem
. 1995 Aug;
270(32):19181-7.
PMID: 7642586
WAF1 binds to cyclin-Cdk complexes and inhibits their activity, causing cell cycle arrest. Previous studies have shown that expression of WAF1 is induced through the p53-dependent pathway; WAF1 is induced...