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K Scott Phillips

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Articles 47
Citations 657
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Recent Articles
1.
Xu Y, Phillips K, Ren D
Acta Biomater . 2024 Aug; 187:253-260. PMID: 39214161
Many medical devices implanted in patients to mitigate diseases and medical conditions have different types of topographic features. While appropriate textures can promote the integration of host cells and reduce...
2.
Hickok N, Li B, Oral E, Zaat S, Armbruster D, Atkins G, et al.
J Orthop Res . 2023 Dec; 42(3):512-517. PMID: 38146070
Antimicrobial strategies for musculoskeletal infections are typically first developed with in vitro models. The In Vitro Section of the 2023 Orthopedic Research Society Musculoskeletal Infection international consensus meeting (ICM) probed...
3.
Lee S, Johnson E, Chediak J, Shin H, Wang Y, Phillips K, et al.
ACS Appl Bio Mater . 2022 Jul; 5(8):3816-3825. PMID: 35816421
The specific topography of biomaterials plays an important role in their biological interactions with cells and thus the safety of medical implants. Antifouling materials can be engineered with topographic features...
4.
Hung B, Simon D, Phillips K, Isayeva I, Shin H
Biomech Model Mechanobiol . 2022 May; 21(4):1117-1131. PMID: 35534762
Recent reports of adverse health effects (e.g., capsular contracture, lymphoma) linked to the absence or presence of texture on soft-tissue implants (e.g., breast implants) suggest surface topography may have pathological...
5.
Wang Y, Borthwell R, Hori K, Clarkson S, Blumstein G, Park H, et al.
J Biomed Mater Res B Appl Biomater . 2022 Mar; 110(8):1932-1941. PMID: 35352867
Preclinical in vitro and in vivo methods to study bacterial interactions with dermal fillers and infection pathogenesis are lacking. In this work, first in vitro methods to assess protein biofouling...
6.
Lee S, Carnicelli J, Getya D, Gitsov I, Phillips K, Ren D
ACS Appl Mater Interfaces . 2021 Apr; 13(15):17174-17182. PMID: 33822590
Bacteria can colonize essentially any surface and form antibiotic resistant biofilms, which are multicellular structures embedded in an extracellular matrix secreted by the attached cells. To develop better biofilm control...
7.
Wang H, Agrawal A, Wang Y, Crawford D, Siler Z, Peterson M, et al.
Sci Rep . 2021 Mar; 11(1):5746. PMID: 33707493
The skin is a barrier and part of the immune system that protects us from harmful bacteria. Because indwelling medical devices break this barrier, they greatly increase the risk of...
8.
Siddam A, Zaslow S, Wang Y, Phillips K, Silverman M, Regan P, et al.
Front Microbiol . 2021 Jan; 11:586657. PMID: 33505365
Non-tuberculous mycobacteria (NTM) are widespread in the environment and are a public health concern due to their resistance to antimicrobial agents. The colonization of surgical heater-cooler devices (HCDs) by the...
9.
Lee S, Phillips K, Gu H, Kazemzadeh-Narbat M, Ren D
Biomaterials . 2020 Dec; 268:120595. PMID: 33360301
Microbes have remarkable capabilities to attach to the surface of implanted medical devices and form biofilms that adversely impact device function and increase the risk of multidrug-resistant infections. The physicochemical...
10.
Wong M, Wang Y, Wang H, Marrone A, Haugen S, Kulkarni K, et al.
Biomed Instrum Technol . 2020 Dec; 54(6):397-409. PMID: 33339032
Standard methods are needed to reliably and efficiently assess bacterial contamination of processed medical devices. This article demonstrates a standard operating procedure (SOP) for fluorescence microscopy-based detection of residual bacteria...