K S Kan
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Explore the profile of K S Kan including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
125
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Recent Articles
1.
Kan K, Anderson V, Leong W, Smith A, Worth A, Stevenson G
J Immunol
. 2001 Jan;
166(2):1320-6.
PMID: 11145716
We describe a two-stage preparation of chemically engineered Ab constructs, employing as modules Fab'gamma from mAb or rAb, and Fc from human normal IgG1. A multivalent, optionally multispecific F(ab')(n) core...
2.
Stevenson G, Anderson V, Kan K, Worth A
J Immunol
. 1997 Mar;
158(5):2242-50.
PMID: 9036971
We describe a method for linking human normal Fc gamma1, via stable thioether bonds emerging from its hinge, to any molecule expressing a free sulfhydryl (SH) group. The Fc hinge...
3.
Harris C, Kan K, Stevenson G, Morgan B
Clin Exp Immunol
. 1997 Feb;
107(2):364-71.
PMID: 9030877
Immunotherapy using MoAbs is inefficient due to limited activation of human effectors by mouse antibodies and multiple protective mechanisms available to host cells against autologous complement. We have used chemically...
4.
Hazra D, Stevenson G, Kan K
Cell Biophys
. 1995 Jun;
26(3):183-6.
PMID: 8521450
Earlier studies described the linkage of silver to antibodies using SH groups generated by the reduction of the SS groups using ascorbic acid (1) analogous to the Thakur and DeFulvio...
5.
Stevenson G, Bell A, Evans T, French R, Glennie M, Hamblin T, et al.
Cell Biophys
. 1994 Jan;
24-25:45-50.
PMID: 7736539
We report two preliminary trials of antibody treatment of B-cell lymphoma. Advanced lymphoma was treated with chimeric FabFc2, in which mouse Fab' gamma is linked to two human Fc gamma...
6.
Kan K, Coleman R
Biochem J
. 1990 Aug;
270(1):241-3.
PMID: 2396983
Infusion of menadione at two different doses [2.7 mg and 5.5 mg in 100 microliters of dimethyl sulphoxide (DMSO)] into perfused rat livers for 30 min caused no or a...
7.
8.
Kan K, Monte M, Parslow R, Coleman R
Biochem J
. 1989 Jul;
261(1):297-300.
PMID: 2637685
By using rat liver perfusion under one-pass conditions with a single pulse of horseradish peroxidase (HRP), the biliary output of HRP was used as an indicator of paracellular permeability change...
9.
Coleman R, Rahman K, Kan K, Parslow R
Biochem J
. 1989 Feb;
258(1):17-22.
PMID: 2930503
The control of biliary phospholipid and cholesterol secretions by bile acid was studied by using the technique of retrograde intrabiliary injection. Taurocholate (TC), a moderately hydrophobic bile acid, taurodehydrocholate (TDHC),...
10.
Kan K, Coleman R
Biochem J
. 1988 Dec;
256(3):1039-41.
PMID: 3146979
The effect of an increase in intracellular Ca2+ concentration on tight-junctional permeability in rat liver was studied by using the calcium ionophore A23187. Infusion of 100 microliters of dimethyl sulphoxide...