K R McCrae
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Explore the profile of K R McCrae including associated specialties, affiliations and a list of published articles.
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36
Citations
1299
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Recent Articles
1.
Shukla M, Sekhon U, Betapudi V, Li W, Hickman D, Pawlowski C, et al.
J Thromb Haemost
. 2016 Dec;
15(2):375-387.
PMID: 27925685
Summary: Background Platelet transfusion applications face severe challenges, owing to the limited availability and portability, high risk of contamination and short shelf-life of platelets. Therefore, there is significant interest in...
2.
Wu M, Barnard J, Kundu S, McCrae K
J Thromb Haemost
. 2015 Aug;
13(10):1928-40.
PMID: 26264622
Background: Elevated levels of endothelial cell (EC)-derived extracellular vesicles (EVs) circulate in patients with antiphospholipid antibodies (APLAs), and APLAs, particularly those against β2 -glycoprotein I (β2 GPI), stimulate EV release...
3.
Leissinger C, Josephson C, Granger S, Konkle B, Kruse-Jarres R, Ragni M, et al.
Thromb Haemost
. 2014 Jun;
112(3):445-58.
PMID: 24919980
The development of antibodies against infused factor VIII (FVIII) in patients with haemophilia A is a serious complication leading to poorly controlled bleeding and increased morbidity. No treatment has been...
4.
Cockrell E, Espinola R, McCrae K
Lupus
. 2008 Oct;
17(10):943-51.
PMID: 18827060
Antiphospholipid antibodies (aPL), the majority of which are directed against beta(2)-glycoprotein I (beta(2)GPI), are associated with an increased incidence of venous and arterial thrombosis. The pathogenesis of antiphospholipid/anti-beta(2)GPI-associated thrombosis has...
5.
Schmaier A, McCrae K
J Thromb Haemost
. 2007 Sep;
5(12):2323-9.
PMID: 17883591
The plasma kallikrein-kinin system consists of the proteins factor XII (FXII), prekallikrein (PK), and high molecular weight kininogen. It was first recognized as a surface-activated coagulation system that is activated...
6.
McCrae K, Bussel J, Mannucci P, Remuzzi G, Cines D
Hematology Am Soc Hematol Educ Program
. 2001 Nov;
:282-305.
PMID: 11722989
Thrombocytopenia in the pregnant patient may result from a number of causes, most of which involve either immune-mediated platelet destruction or platelet consumption. Many of these disorders share clinical and...
7.
Zhang J, Claffey K, Sakthivel R, Darzynkiewicz Z, Shaw D, Leal J, et al.
FASEB J
. 2000 Dec;
14(15):2589-600.
PMID: 11099478
We previously reported that the binding of two-chain high molecular weight kininogen (HKa) to endothelial cells may occur through interactions with endothelial urokinase receptors. Since the binding of urokinase to...
8.
Sakthivel R, Zhang J, Strickland D, Gafvels M, McCrae K
J Biol Chem
. 2000 Sep;
276(1):555-62.
PMID: 11010963
The very low density lipoprotein receptor (VLDL-R) binds and internalizes several ligands, including very low density lipoprotein (VLDL), urokinase-type plasminogen activator:plasminogen activator inhibitor type 1 complexes, lipoprotein lipase, and the...
9.
Ma K, Simantov R, Zhang J, SILVERSTEIN R, Hajjar K, McCrae K
J Biol Chem
. 2000 May;
275(20):15541-8.
PMID: 10809787
Beta(2)-glycoprotein I (beta(2)GPI) is an abundant plasma phospholipid-binding protein and an autoantigen in the antiphospholipid antibody syndrome. Binding of beta(2)GPI to endothelial cells targets them for activation by anti-beta(2)GPI antibodies,...
10.
Mahalati K, Dawson R, COLLINS J, Bell W, McCrae K, Martin Jr J
J Clin Apher
. 1999 Aug;
14(2):69-78.
PMID: 10440942
The spectrum of complications with pre-eclampsia, which may include AFLP (acute fatty liver of pregnancy) as well as the HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets), is resolved...