K R Iyer
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Explore the profile of K R Iyer including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
151
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Recent Articles
1.
Lauro A, Panaro F, Iyer K
J Visc Surg
. 2017 Apr;
154(2):105-114.
PMID: 28434656
Aim Of The Study: To report the current activity of intestinal transplantation in Europe (EU) and Unites States of America (USA), underlining outcomes in the last 5 years and discussing...
2.
Shah T, Kamble S, Patil P, Iyer K
Indian J Pharm Sci
. 2015 Dec;
77(4):382-90.
PMID: 26664053
The catalytic activity of cytochrome P450 enzymes is known to be affected by presence of organic solvents in in vitro assays. However, these effects tend to be variable and depend...
3.
Patil P, Kamble S, Shah T, Iyer K
Indian J Pharm Sci
. 2015 Jul;
77(3):283-9.
PMID: 26180273
Organic solvents used for solubilization of the substrates/NCEs are known to affect the activity of cytochrome P450 enzymes. Further, this effect varies with the solvents used, the substrates and CYP450...
4.
Kadam R, Iyer K
Indian J Pharm Sci
. 2010 Apr;
70(1):85-8.
PMID: 20390086
Aldehyde oxidase activity containing fractions from rabbit, guinea pig, rat and mouse livers were obtained by heat treatment and ammonium sulfate precipitation. Aldehyde oxidase activity was observed in rabbit and...
5.
Iyer K, Horslen S, Torres C, Vanderhoof J, Langnas A
J Pediatr Surg
. 2004 Mar;
39(3):340-4.
PMID: 15017549
Background/purpose: Parenteral nutrition (PN) is life saving in short bowel syndrome. However, long-term parenteral nutrition is frequently complicated by a syndrome of progressive cholestatic liver disease that is considered to...
6.
Iyer K, Srinath C, Horslen S, Fox I, Shaw B, Sudan D, et al.
J Pediatr Surg
. 2002 Jan;
37(2):151-4.
PMID: 11819189
Background/purpose: The aim of this study was to determine causes of late graft loss and long-term outcome after isolated intestinal transplantation in children at a single center. Methods: All children...
7.
Sudan D, Iyer K, Deroover A, Chinnakotla S, Fox Jr I, Shaw Jr B, et al.
Transplantation
. 2001 Dec;
72(11):1846-8.
PMID: 11740401
The most common application of small bowel transplantation is for the patient with parenteral nutrition-induced liver failure. In this setting, the small intestine is transplanted simultaneously with the liver. We...
8.
Henne K, Fisher M, Iyer K, Lang D, TRAGER W, Rettie A
Biochemistry
. 2001 Jul;
40(29):8597-605.
PMID: 11456500
The active site topography of rabbit CYP4B1 has been studied relative to CYP2B1 and CYP102 using a variety of aromatic probe substrates. Oxidation of the prochiral substrate cumene by CYP4B1,...
9.
Iyer K, Sinz M
Chem Biol Interact
. 1999 Jun;
118(2):151-69.
PMID: 10359459
The role of drug metabolism in drug discovery (lead compound selection) and the traditional role of identifying the enzymes involved in biotransformation pathways (reaction phenotyping) have both relied heavily on...
10.
He K, Iyer K, Hayes R, Sinz M, Woolf T, Hollenberg P
Chem Res Toxicol
. 1998 May;
11(4):252-9.
PMID: 9548795
Grapefruit juice has been found to significantly increase oral bioavailability of several drugs metabolized by cytochrome P450 3A4 (P450 3A4) through inhibiting the enzymatic activity and decreasing the content of...